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L 054522
somatostatin receptor subtype 2 agonist; structure in first source
Also Known As:
L 055,522; L-054,522; L-054522
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzimidazoles: 245
L 054522: 2
Indoles: 200
L 054522: 2
Experts
1.
Forstreuter, F
: 2 articles (05/2001 - 02/2001)
2.
Held-Feindt, J
: 2 articles (05/2001 - 02/2001)
3.
Mentlein, R
: 2 articles (05/2001 - 02/2001)
4.
Eichler, O
: 1 article (05/2001)
5.
Pufe, T
: 1 article (02/2001)
Related Diseases
1.
Glioma (Gliomas)
02/19/2001 - "
After stimulation of cultivated human U343 glioma cells with somatostatin, octreotide (sst2-, sst3- and sst5-selective peptide agonist) or the sst2-selective non-peptide agonist L-054,522 multiple signal transduction pathways are induced: elevated cAMP levels are reduced, protein tyrosine phosphatases (especially SHP2) are activated and mitogen-activated protein kinases are inhibited.
"
05/15/2001 - "
Since somatostatin receptors, especially of the subtype sst2A, are constantly over-expressed in gliomas, we investigated the influence of somatostatin and the receptor subtype-selective peptide/non-peptide agonists octreotide and L-054,522 on the secretion of the most important angiogenesis factor produced by gliomas, vascular endothelial growth factor (VEGF).
"
Related Drugs and Biologics
1.
Octreotide (Sandostatin)
2.
Somatostatin (Somatotropin Release-Inhibiting Factor)
3.
Peptides (Polypeptides)
4.
Angiogenesis Inducing Agents (Angiogenesis Factor)
5.
Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.
Mitogen-Activated Protein Kinases
7.
Somatostatin Receptors (Somatostatin Receptor)
8.
Protein Tyrosine Phosphatases