interferon-alpha B-D

a hybrid IFN constructed with an N-terminal part & a C-terminal part of IFNalpha B (-alpha1) combined with an IFNalpha D (-alpha8)-derived middle part (IFNalpha BDBB)

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Networked: 6 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Infections 04/01/1996 - "Tolerability and activity of a new recombinant interferon-alpha B/D hybrid in patients with HIV-1 infection." 06/01/1989 - "Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections." 06/01/1989 - "Treatment of mice infected with Rauscher (RMLV) or Friend (FMLV) murine leukemia viruses at an early stage of disease (beginning at day 0 and continuing every other day for 21 days) with 5 x 10(7) units/kg body weight of a cross-species-active recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D) was more effective in FMLV than in RMLV infections. " 08/01/1996 - "The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques."
2.	Encephalitis (Encephalitis, Rasmussen) 11/01/1999 - "The efficacy of recombinant human interferon alpha B/D in experimental HSV-1 encephalitis was investigated in the murine system. " 11/01/1999 - "Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis."
3.	Body Weight (Weight, Body) 06/01/1989 - "Treatment of mice infected with Rauscher (RMLV) or Friend (FMLV) murine leukemia viruses at an early stage of disease (beginning at day 0 and continuing every other day for 21 days) with 5 x 10(7) units/kg body weight of a cross-species-active recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D) was more effective in FMLV than in RMLV infections. "
4.	Chronic Hepatitis B 08/01/1998 - "A novel recombinant interferon-alpha B/D hybrid was applied to assess tolerability, antiviral effect, and biological activity in chronic hepatitis B. " 08/01/1998 - "Tolerance and antiviral effects of high-dose interferon-alpha B/D in patients with chronic hepatitis B."
5.	Virus Diseases (Viral Diseases) 04/01/1989 - "The antiviral potential of a novel cross-species active, recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D), was evaluated for its efficiacy in cultured human monocytes and in several murine models of viral disease. "

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Interferon-alpha (Interferon Alfa)
3.	Acyclovir (Aciclovir)
4.	interferon-alpha 8