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Sm-p40 antigen

displays homology to small heat shock proteins and alpha-crystallins; has been sequenced

Also Known As:

Smp40 antigen

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protozoan Proteins
    - Protozoan Antigens: 1
      - Sm-p40 antigen: 3
Biological Factors: 2472
- Antigens: 143924
  - Protozoan Antigens: 1
    - Sm-p40 antigen: 3

Experts

1.	Czerkinsky, C: 1 article (11/2001)
2.	Hernandez, H J: 1 article (11/2001)
3.	Holmgren, J: 1 article (11/2001)
4.	Lakew, M: 1 article (11/2001)
5.	Li, B L: 1 article (11/2001)
6.	Mielcarek, N: 1 article (11/2001)
7.	Stadecker, M J: 1 article (11/2001)
8.	Sun, J B: 1 article (11/2001)

Related Diseases

1.	Schistosomiasis (Bilharziasis) 11/01/2001 - "These results indicate that mucosal administration of SEA or purified Sm-p40 antigen in conjunction with CTB is highly effective in curtailing immunopathologic manifestations of schistosomiasis in vivo in infected hosts."
2.	Granuloma 05/01/1998 - "The Sm-p40 antigen, a major component of schistosome eggs, elicits a strong CD4+ Th cell response in H-2k mice that correlates with intense granuloma formation; in contrast, its immunogenicity is relatively minor during infection of other mouse strains that develop smaller granulomas. " 09/01/1998 - "Interestingly, the cells responding to peptide 10 and to the Sm-p40 antigen only secreted IL-2 and IFN-gamma, but not IL-4 and IL-10, indicating that they are entirely of the Th-1-type, a subset with demonstrated capacity to mediate egg granuloma formation. "
3.	Infections 05/01/1998 - "The Sm-p40 antigen, a major component of schistosome eggs, elicits a strong CD4+ Th cell response in H-2k mice that correlates with intense granuloma formation; in contrast, its immunogenicity is relatively minor during infection of other mouse strains that develop smaller granulomas. "

Related Drugs and Biologics

1.	Interleukin-10 (Interleukin 10)
2.	Interleukin-4 (Interleukin 4)
3.	Peptides (Polypeptides)
4.	Interleukin-2 (IL2)

Related Therapies and Procedures

1.	Mucosal Administration