glucosyltransferase D (GtfD)

from Steptococcus mutans; produces a soluble glucan with predominantly alpha1,6-linked glucosyl units; rom a vancomycin-producing strain of Amycolatopsis orientalis; GenBank AF351621

Also Known As:

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brady, L J: 1 article (02/2016)
2.	Crowley, P J: 1 article (02/2016)
3.	Fujita, K: 1 article (06/2015)
4.	Matsumi, Y: 1 article (06/2015)
5.	Matsumoto-Nakano, M: 1 article (06/2015)
6.	Morikawa, Y: 1 article (06/2015)
7.	Takashima, Y: 1 article (06/2015)
8.	Yanagida, K: 1 article (06/2015)
9.	Kim, Jae-Gon: 1 article (08/2011)
10.	Kim, Mi-Ah: 1 article (08/2011)

Related Diseases

1.	Dental Caries (Decay, Dental) 08/01/2011 - "In this study, we generated monoclonal antibodies against the N-terminus of GtfD (anti-GtfDN antibody) in an initial attempt to investigate its preventive efficacy against dental caries. " 08/01/2011 - "Glucosyltransferases GtfB, GtfC, and GtfD of Streptococcus mutans are virulent factors involved in dental caries. " 06/01/2010 - "Streptococcus mutans is a major pathogen of dental caries and occasionally isolated from the blood of patients with infective endocarditis, though the association of its cell-surface glucosyltransferases (GTFB, GTFC, and GTFD) with pathogenicity for infective endocarditis remains to be elucidated. " 06/01/2008 - "Streptococcus mutans, considered to be the primary pathogen causing dental caries, is able to utilize sucrose as a nutrient source, partially for the production of intracellular storage components and for the production of extracellular glucans via the glucosyltransferases GtfB, GtfC, and GtfD. " 06/01/2015 - "Glucan-binding proteins (Gbps) of Streptococcus mutans, a major pathogen of dental caries, mediate the binding of glucans synthesized from sucrose by the action of glucosyltransferases (GTFs) encoded by gtfB, gtfC, and gtfD. "
2.	Virus Diseases (Viral Diseases) 08/01/2002 - "In addition to viral infections, streptococci and their associated antigen, GtfD, may be involved in the disease process of RAU, especially in the exacerbation stage."
3.	Endocarditis 06/01/2010 - "Streptococcus mutans is a major pathogen of dental caries and occasionally isolated from the blood of patients with infective endocarditis, though the association of its cell-surface glucosyltransferases (GTFB, GTFC, and GTFD) with pathogenicity for infective endocarditis remains to be elucidated. "
4.	Dental Plaque 05/01/2023 - "This bacterium expresses three genetically distinct types of glucosyltransferases named GtfB (GTF-I), GtfC (GTF-SI) and GtfD (GTF-S) that play critical roles in the development of dental plaque. "
5.	Autolysis 02/01/2016 - "Here we used a genetic approach to characterize the effects of deletion of genes encoding the ribosome-associated chaperone RopA (Trigger Factor), the surface-localized foldase PrsA, and the membrane-localized chaperone insertases YidC1 and YidC2, both singly and in combination, on bacterial growth, chain length, self-aggregation, cell surface hydrophobicity, autolysis, and antigenicity of surface proteins P1 (AgI/II, PAc), WapA, GbpC, and GtfD. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Glucosyltransferases
3.	Sucrose (Saccharose)
4.	Glucans
5.	Enzymes
6.	inulosucrase (fructosyltransferase)
7.	Membrane Proteins (Integral Membrane Proteins)
8.	Antigens
9.	glucan-binding proteins