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U 0126 (UO 126)

protein kinase kinase inhibitor; structure in first source
Also Known As:
UO 126; 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene; U-0126; U0126; U0126 cpd; U126 cpd; UO-126; UO126
Networked: 741 relevant articles (48 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Edvinsson, Lars: 12 articles (01/2019 - 04/2007)
2. Armstead, William M: 10 articles (05/2012 - 01/2003)
3. Marampon, Francesco: 6 articles (10/2020 - 12/2005)
4. Cao, Jun-Li: 6 articles (01/2018 - 04/2005)
5. Chen, Yuanli: 5 articles (01/2022 - 02/2015)
6. Duan, Yajun: 5 articles (01/2022 - 02/2015)
7. Han, Jihong: 5 articles (01/2022 - 02/2015)
8. Warfvinge, Karin: 5 articles (01/2021 - 01/2015)
9. Ciccarelli, Carmela: 5 articles (09/2018 - 12/2005)
10. Chen, Jun: 5 articles (01/2017 - 06/2005)

Related Diseases

1. Infarction (Infarctions)
2. Neoplasms (Cancer)
3. Cardiomegaly (Heart Hypertrophy)
01/01/2016 - "In addition, the requirement of the MEK1/2-ERK1/2 signaling for RGS12-mediated cardiac hypertrophy was confirmed in rescue experiments using the MEK1/2-specific inhibitor U0126. "
04/01/2015 - "In view of the potent and selective activity of the ERK inhibitor U0126, this agent warrants further investigation as a candidate for preventing hyperphosphate-induced cardiac hypertrophy in CKD and dialysis patients."
01/01/2019 - "Moreover, ERK1/2 was identified as a regulator of RNA pol III, and ERK1/2 inhibition by U0126 significantly repressed Maf1 knockdown-promoted cardiac hypertrophy accompanied by suppressed RNA pol III transcription. "
02/18/2016 - "Analyses of the underlying molecular mechanism revealed that ACE3-mediated protection against cardiac hypertrophy by suppressing the activation of mitogen-activated protein kinase kinase (MEK)-regulated extracellular signal-regulated protein kinase (ERK1/2) signaling, which was further evidenced by the observation that inhibition of the MEK-ERK1/2 signaling by U0126 rescued the exacerbated hypertrophic phenotype in ACE3-deficient mice. "
01/01/2016 - "Furthermore, we demonstrated that GAS6 activated the mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 pathway during pressure overload-induced cardiac hypertrophy, and the pharmacological mitogen-activated protein kinase kinase 1/2 inhibitor U0126 almost completely reversed GAS6 overexpression-induced cardiac hypertrophy and fibrosis, resulting in improved cardiac function. "
4. Hypoxia (Hypoxemia)
5. Ischemia

Related Drugs and Biologics

1. Mitogen-Activated Protein Kinase Kinases (MEKs)
2. 2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one
3. Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4. Proteins (Proteins, Gene)
5. Mitogen-Activated Protein Kinases
6. Phosphotransferases (Kinase)
7. Protein Kinases (Protein Kinase)
8. Mitogen-Activated Protein Kinase 3
9. Estrogens (Estrogen)
10. MAP Kinase Kinase 1

Related Therapies and Procedures

1. Spinal Injections
2. Transplantation
3. Intravenous Administration
4. Acupuncture Points (Acupuncture Point)
5. Oral Administration