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KW 2170

structure in first source

Also Known As:

KW-2170

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - KW 2170: 5
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - KW 2170: 5

Experts

1.	Bolger, Graeme B: 1 article (12/2010)
2.	De Souza, Paul L: 1 article (12/2010)
3.	Fujimori, Matt: 1 article (12/2010)
4.	Khoo, Kei Siong: 1 article (12/2010)
5.	Lim, Robert: 1 article (12/2010)
6.	North, Scott: 1 article (12/2010)
7.	Phillips, James: 1 article (12/2010)
8.	Spiridonidis, Harris: 1 article (12/2010)
9.	Alvarez, Ronald D: 1 article (08/2006)
10.	Barnes, Mack N: 1 article (08/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2004 - "Phase I and pharmacokinetic study of KW-2170, a novel pyrazoloacridone compound, in patients with malignant tumors." 11/01/2004 - "A secondary purpose was to assess tumor response to KW-2170. " 03/01/1998 - "KW-2170 showed significant antitumor activity against 17 human tumor xenografts of a total of 24 tumors tested and the total tumor response rate by treatment with KW-2170 was significantly higher than that by ADM (70.8 versus 58.3%). " 03/01/1998 - "In particular, human lung carcinoma was highly sensitive to KW-2170, and a marked tumor regression was observed on Lu-65 and Lu-99 human lung carcinoma xenograft models. " 03/01/1998 - "These results indicate that KW-2170 has a very potent antitumor activity and is feasible as a new antitumor drug against ADM-refractory solid tumors in clinics."
2.	Prostatic Neoplasms (Prostate Cancer) 12/01/2010 - "A phase II trial of weekly i.v. KW-2170 in advanced castrate-resistant prostate cancer."
3.	Neutropenia 11/01/2004 - "The primary DLT of KW-2170 in this study was neutropenia, with a MTD of 53 mg/m2.A significant linear relationship was observed between neutropenia and AUC 0- infinity. "
4.	Cardiotoxicity 08/01/2006 - "KW-2170 is a novel DNA intercalating agent whose mechanism of action is similar to doxorubicin HCl, yet is associated with less cardiac toxicity. "
5.	Sarcoma 180 03/01/1998 - "KW-2170 exhibited antitumor activity superior to adriamycin (ADM) against Sarcoma 180, breast carcinoma MM102 and fibrosarcoma Meth A inoculated s.c. "

Related Drugs and Biologics

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4.	Intercalating Agents
5.	DNA (Deoxyribonucleic Acid)
6.	Antineoplastic Agents (Antineoplastics)
7.	Alkylating Agents