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nephrin

gene nephrin is mutated in congenital nephrotic syndrome; amino acid sequence in first source; GenBank F19541; RefSeq NM_019459 (mouse), NM_004646 (human), NM_022628 (rat)

Also Known As:

CNF protein, human; NPHS1 protein, human; Nphs1 protein, mouse; Nphs1 protein, rat; nephrosis 1 homolog, nephrin (human) protein, mouse; nephrosis 1 homolog, nephrin (human) protein, rat; nephrosis 1, congenital, Finnish type (nephrin) protein, human

Networked: 467 relevant articles (26 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - nephrin: 467

Experts

1.	Kawachi, Hiroshi: 25 articles (08/2014 - 01/2002)
2.	Tryggvason, Karl: 17 articles (06/2011 - 02/2002)
3.	Shimizu, Fujio: 12 articles (08/2009 - 01/2002)
4.	Saleem, Moin A: 11 articles (01/2015 - 10/2002)
5.	Jalanko, Hannu: 11 articles (12/2014 - 02/2002)
6.	Holthöfer, Harry: 11 articles (05/2012 - 01/2002)
7.	Tryggvason, K: 11 articles (04/2006 - 06/2000)
8.	Camussi, Giovanni: 10 articles (09/2009 - 04/2003)
9.	Ruotsalainen, Vesa: 10 articles (11/2004 - 02/2002)
10.	Holzman, Lawrence B: 7 articles (10/2015 - 05/2003)

Related Diseases

1.	Proteinuria 01/01/2011 - "Shen-qi-di-huang decoction decreases proteinuria, protects kidney function, and ameliorates histopathology in ADR-induced rats by preserving nephrin expression." 01/01/2011 - "Chronic administration of ANG-(1-7) normalized arterial pressure, reduced glycemia and triglyceridemia, improved proteinuria, and ameliorated structural alterations in the kidney of SHRSP as shown by a restoration of glomerular nephrin levels as detected by immunofluorescence. " 01/01/2008 - "The present study evaluates the effects of Ang II infusion in rats on podocyte nephrin expression and apoptosis and the molecular mechanisms involved in Ang II-induced proteinuria and mesangial expansion. " 08/01/2007 - "Many studies tried to demonstrate a relationship between proteinuria and changes in nephrin in various forms of glomerular diseases including DN, but the results are not consistent. " 03/01/2007 - "Pharmacological in vitro and in vivo inhibition studies of GSK3 suggested that GSK3 activity decreased in injured podocytes and this change partially contributed to the decrease in nephrin and increase in Snail and proteinuria. "
2.	Albuminuria 11/01/2012 - "Peroxisome proliferator-activated receptor-δ activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes." 03/01/2011 - "In the present study, we examined whether and how nephrin expression is sustained by podocytes during the HGF-mediated attenuation of albuminuria. " 05/01/2002 - "This study examines the possible relationship between nephrin expression and albuminuria in normotensive and hypertensive diabetic rats. " 10/01/2015 - "In podocyte-specific KLF4 knockout mice, the effect of ARB on albuminuria and the nephrin promoter methylation was attenuated. " 06/01/2014 - "Transient restoration of KLF4 expression in podocytes of diseased glomeruli in vivo, either by gene transfer or transgenic expression, resulted in a sustained increase in nephrin expression and a decrease in albuminuria. "
3.	Nephrotic Syndrome (Syndrome, Nephrotic) 05/01/2008 - "Thus our results demonstrate that WLS ameliorates ADR-induced nephrotic syndrome in rats possibly by suppressing ADR-induced hyperactivity of renal renin-angiotensin system to modulate renal nephrin gene expression, thereby protecting podocyte from injury." 11/01/2002 - "Our study provides further evidence that loss of function of the nephrin gene is the main cause of congenital nephrotic syndrome of the Finnish type in Italian patients." 07/01/2015 - "Loss of nephrin during the development leads to the congenital nephrotic syndrome in children. " 08/06/2014 - "Nephrin, a gene product of NPHS1, a gene for a congenital nephrotic syndrome of Finnish type, constitutes an extracellular domain of the slit diaphragm. " 12/01/2013 - "Novel and known nephrin gene (NPHS1) mutations in two Greek cases with congenital nephrotic syndrome including a complex genotype."
4.	Diabetic Nephropathies (Diabetic Nephropathy) 07/01/2013 - "Collectively, the present studies provide evidence that Ang II plays a relevant role in perpetuating glomerular injury in experimental and human diabetic nephropathy via persistent activation of Notch1 and Snail signaling in podocytes, eventually resulting in down-regulation of nephrin expression, the integrity of which is crucial for the glomerular filtration barrier." 01/01/2009 - "We present the analysis of an intronic polymorphism of the nephrin gene and its relationship to the development of diabetic nephropathy in a study of diabetes type 1 and type 2 patients. " 04/01/2003 - "This study does not support an involvement of the coding region of the nephrin gene in the pathogenesis of diabetic nephropathy in type 1 diabetic patients." 08/01/2014 - "Podocyte dysfunction is a detrimental feature in diabetic nephropathy, with loss of nephrin integrity contributing to diabetic podocytopathy. " 07/01/2013 - "In vitro changes of the Snail/nephrin axis were similar to those in renal biopsy specimens of Zucker diabetic fatty rats and patients with advanced diabetic nephropathy, and were normalized by pharmacological inhibition of the renin-angiotensin system. "
5.	Fibrosis (Cirrhosis) 09/01/2013 - "Morphologically, HHcy-associated glomerulosclerosis, fibrosis, podocyte foot process effacement and loss of podocyte nephrin, were significantly improved by FA. " 01/01/2015 - "Meanwhile, CTX upregulated the protein level of podocyte-specific nephrin and downregulated the level of fibrosis-related TGF-β. " 11/01/2013 - "EET-B treatment in Dahl SS rats markedly reduced urinary albumin and nephrin excretion by 60% to 75% along with 30% to 60% reductions in glomerular injury, intratubular cast formation, and kidney fibrosis without affecting blood pressure. " 06/01/2011 - "Nephrin knockout embryos showed abnormal epicardial cell morphology and, at later stages of development, a reduced number of coronary vessels due to increased apoptosis, and in addition, cardiac fibrosis. " 08/01/2014 - "Diabetic miR-29a transgenic mice had better nephrin levels, podocyte viability, and renal function and less glomerular fibrosis and inflammation reaction compared with diabetic wild-type mice. "

Related Drugs and Biologics

1.	NPHS2 protein
2.	podocalyxin
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Fibronectins (Fibronectin)
5.	Creatinine
6.	Antibodies
7.	Messenger RNA (mRNA)
8.	Desmin
9.	Collagen
10.	Streptozocin (Streptozotocin)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Nephrectomy
3.	Transplantation (Transplant Recipients)
4.	Homologous Transplantation (Allograft)
5.	Drug Therapy (Chemotherapy)