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MDP(lysyl)GDP

a nontoxic muramyl dipeptide derivative, inhibits cytokine production by activated macrophages

Also Known As:

3-O-(N-acetylmuramyl-L-lysyl-D-iso)-2-di-on-glycine

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - MDP(lysyl)GDP: 1

Related Diseases

1.	Allergic Contact Dermatitis 07/01/1998 - "This study examines whether a water soluble 3-O-[N-acetylmuramyl-L-lysyl-D-iso]-2-di-on-glycine [MDP(Lysyl)GDP], a nontoxic and nonpyrogenic derivative of muramyl dipeptide (MDP), can inhibit the in vitro production of inflammatory mediators by lipopolysaccharide- or interferon-gamma-activated macrophages, and whether such an inhibitory effect can translate into in vivo protection of mice from irritant and allergic contact dermatitis. "
2.	Otitis 07/01/1998 - "Likewise, oral treatment with MDP(Lysyl)GDP at days -3, -2, and -1 before elicitation with oxazolone also significantly inhibited ear inflammation. " 07/01/1998 - "In mouse models of phorbol ester- and oxazolone-induced ear inflammation, topical application of MDP(Lysyl)GDP significantly suppressed ear swelling in a dose-dependent manner. "
3.	Inflammation (Inflammations) 07/01/1998 - "MDP(Lysyl)GDP, a nontoxic muramyl dipeptide derivative, inhibits cytokine production by activated macrophages and protects mice from phorbol ester- and oxazolone-induced inflammation."

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Irritants (Vesicants)
3.	Interferon-gamma (Interferon, gamma)
4.	Glycine (Aminoacetic Acid)
5.	Acetylmuramyl-Alanyl-Isoglutamine
6.	Cytokines
7.	Phorbol Esters
8.	Oxazolone