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SM 18400

Also Known As:

9-chloro-5-(p-aminomethyl-o-(carboxymethoxy)phenylcarbamoylmethyl)-6,7-dihydro-1H,5H-pyrido(1,2,3-de)quinoxaline-2,3-dione hydrochloride trihydrate; SM-18400; SM18400

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - SM 18400: 3

Experts

1.	Katayama, Seiji: 1 article (01/2006)
2.	Nagata, Ryu: 1 article (01/2006)
3.	Ohtani, Ken-Ichi: 1 article (01/2006)
4.	Shimago, Kozo: 1 article (01/2006)
5.	Tanaka, Hiroyasu: 1 article (01/2006)
6.	Akao, Kyoko: 1 article (01/2003)
7.	Ito, Masaki: 1 article (01/2003)
8.	Kanamaru, Hiroshi: 1 article (01/2003)
9.	Kataoka, Masaki: 1 article (01/2003)
10.	Kon-Ya, Yutaka: 1 article (01/2003)

Related Diseases

1.	Stroke (Strokes) 01/01/2006 - "In fact, SM-18400 and SM-31900 exhibited efficacy in several animal stroke models using intravenous infusion protocols. "
2.	Brain Edema (Cerebral Edema) 07/21/2000 - "These findings suggest that NMDA receptors participate in the increase in the mortality rate, deterioration of neurological signs, and formation of brain edema following ischemic brain damage in the SHR-BCAo model, and that SM-18400 can prevent ischemic insults." 07/21/2000 - "We examined the effects of the selective NMDA receptor glycine-binding site antagonist SM-18400 on the mortality rate, deterioration of neurological signs, and formation of brain edema in the SHR-BCAo model. "
3.	Body Weight (Weight, Body) 01/01/2003 - "The in vitro intrinsic clearance (CL(int), ml/min/mg cytosolic protein) of N-acetyltransferase (NAT) activities of dog liver cytosol towards SM-18400 and hepatic N-acetylation clearance (CL(NAc), ml/min/kg body weight) estimated by well-stirred model were both only 5% of the respective rat value, well reflecting the relative in vivo CL(NAc)/CL(tot) ratios. "

Related Drugs and Biologics

1.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
2.	Proteins (Proteins, Gene)
3.	Glycine (Aminoacetic Acid)
4.	Acetyltransferases
5.	SM 31900
6.	N-acetyltalosaminuronic acid (NAT)

Related Therapies and Procedures

1.	Intravenous Infusions