prefoldin

prefoldin transports unfolded proteins to cytosolic chaperonin (c-cpn); it consists of subunits pfd1-pfd6; RefSeq NM_002622 (PFDN1, human); NM_011070 (Pfdn2, mouse); NM_012394 (PFDN2, human); NM_002623 (PFDN4, human)

Also Known As:

GimC protein, archaea; PFD1 protein, S cerevisiae; PFD1 protein, human; PFDN1 protein, human; PFDN2 protein, human; PFDN4 protein, human; Pfdn2 protein, mouse; Prefoldin subunit 1 protein, S cerevisiae; YJL179W protein, S cerevisiae; prefoldin 1 protein, human; prefoldin 2 protein, human; prefoldin 2 protein, mouse; prefoldin 4 protein, human; prefoldin protein, S cerevisiae

Networked: 47 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Molecular Chaperones: 1279
    - prefoldin: 47

Experts

1.	Sun, Jing: 3 articles (05/2022 - 12/2015)
2.	Hu, Haiyang: 2 articles (05/2022 - 01/2021)
3.	Pan, Mingyu: 2 articles (05/2022 - 01/2021)
4.	Wang, Chen: 2 articles (05/2022 - 01/2021)
5.	Wang, Quanyi: 2 articles (05/2022 - 01/2021)
6.	Wang, Xinxia: 2 articles (05/2022 - 01/2021)
7.	Yin, Yue: 2 articles (05/2022 - 01/2021)
8.	Wei, Wenxiang: 2 articles (01/2021 - 11/2014)
9.	Djouder, Nabil: 2 articles (10/2020 - 11/2016)
10.	Perna, Cristian: 2 articles (10/2020 - 11/2016)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 11/01/2014 - "To explore the effect and molecular mechanism of the unconventional prefoldin RPB5 interactor (URI) in hepatocellular carcinoma HepG2 cells. " 11/14/2019 - "Unconventional prefoldin RNA polymerase II subunit 5 interactor (URI1) has emerged as an oncogenic driver in hepatocellular carcinoma (HCC). " 04/01/2022 - "Prefoldin and prefoldin-like complex subunits as predictive biomarkers for hepatocellular carcinoma immunotherapy." 01/01/2013 - "Multiple studies have recently demonstrated the oncogenic property of URI (or RMP, a member of the prefoldin family of molecular chaperones) during progression of hepatocellular carcinoma, ovarian cancer, and possibly prostate cancer. " 12/08/2014 - "In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. "
2.	Ovarian Neoplasms (Ovarian Cancer) 03/29/2019 - "Unconventional prefoldin RPB5 interactor (URI, or RMP, a member of the prefoldin family of molecular chaperones) exhibits oncogenic activity in several types of cancer, including ovarian cancer. " 01/01/2013 - "Multiple studies have recently demonstrated the oncogenic property of URI (or RMP, a member of the prefoldin family of molecular chaperones) during progression of hepatocellular carcinoma, ovarian cancer, and possibly prostate cancer. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2013 - "Multiple studies have recently demonstrated the oncogenic property of URI (or RMP, a member of the prefoldin family of molecular chaperones) during progression of hepatocellular carcinoma, ovarian cancer, and possibly prostate cancer. "
4.	Neoplasms (Cancer) 01/01/2023 - "URI, a prefoldin family member, has been implicated roles in cancer development. " 01/01/2020 - "The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine." 01/01/2020 - "Prefoldin subunits (PFDN), primarily known for co-chaperone function associated with cytoskeletal rearrangement, have been found involved in epithelial-mesenchymal transition (EMT) and cancer progression. " 01/01/2018 - "Given that URI1 is overexpressed in many types of cancer, it is surprising that the URI1 prefoldin complex has been overlooked. " 01/01/2015 - "Prevalence of the Prefoldin Subunit 5 Gene Deletion in Canine Mammary Tumors."
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 11/01/2019 - "Dysfunction of prefoldin is one of the causes of neurodegenerative diseases such as Alzheimer's disease. " 09/27/2013 - "These results suggest that prefoldin plays a role in quality control against protein aggregation and that dysfunction of prefoldin is one of the causes of neurodegenerative diseases. " 01/01/2020 - "Prefoldin plays a crucial role in the pathogenesis of common neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, and Huntington's disease). "

Related Drugs and Biologics

1.	Molecular Chaperones (Chaperone, Molecular)
2.	Proteins (Proteins, Gene)
3.	RNA Polymerase II (RNA Polymerase B)
4.	Biomarkers (Surrogate Marker)
5.	DNA (Deoxyribonucleic Acid)
6.	Oncogene Proteins (Oncogene Protein)
7.	RNA (Ribonucleic Acid)
8.	Phosphotransferases (Kinase)
9.	Peptides (Polypeptides)
10.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)

Related Therapies and Procedures

1.	Immunotherapy