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tanespimycin (17AAG)

an aminoquinone macrocyclic compound; shares the ability of geldanamycin to bind to heat shock protein 90 and GRP94; IPI-504 is the hydroquinone chloride salt which is more water soluble; structure in first source
Also Known As:
17AAG; 17-(allylamino)-17-demethoxy-geldanamycin; 17-(allylamino)-17-demethoxygeldanamycin; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; 17-allyl-aminogeldanamycin; 17-allylamino-17-demethoxygeldanamycin; 17-allylamino-17-demethoxygeldanamycin hydroquinone; 17-allylamino-17-demethoxygeldanamycin hydroquinone salt; 17-allylamino-geldanamycin; 17-allylaminogeldanamycin; CNF1010; IPI 493; IPI 504; IPI-493; IPI-504; IPI493; IPI504; NSC 330507; NSC-330507; retaspimycin hydrochloride; ((4E,6E,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaen-9-yl) carbamate
Networked: 579 relevant articles (55 outcomes, 150 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rosen, Neal: 22 articles (04/2012 - 02/2002)
2. Workman, Paul: 21 articles (11/2018 - 01/2002)
3. Solit, David B: 17 articles (04/2012 - 02/2002)
4. Erlichman, Charles: 13 articles (08/2015 - 02/2005)
5. Normant, Emmanuel: 13 articles (11/2013 - 07/2006)
6. Egorin, Merrill J: 12 articles (04/2012 - 06/2003)
7. Ivy, S Percy: 12 articles (04/2012 - 05/2005)
8. Banerji, Udai: 8 articles (11/2018 - 11/2003)
9. Neckers, Len: 8 articles (01/2013 - 02/2003)
10. Scher, Howard I: 8 articles (07/2012 - 05/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Pancreatic Neoplasms (Pancreatic Cancer)
4. Glioma (Gliomas)
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. Heat-Shock Proteins (Heat-Shock Protein)
2. geldanamycin
3. STA 9090
4. Trastuzumab (Herceptin)
5. Proteins (Proteins, Gene)
6. Paclitaxel (Taxol)
7. 17- (dimethylaminoethylamino)- 17- demethoxygeldanamycin
8. Hormones (Hormone)
9. Rifabutin (Ansamycin)
10. Cyclin D1

Related Therapies and Procedures

1. Therapeutics
2. Radiotherapy
3. Drug Therapy (Chemotherapy)
4. Castration
5. Immunotherapy