luliconazole

structure in first source

Also Known As:

(2E)-((4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene)(1H-imidazol-1-yl)acetonitrile; 4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile; Lulicon; NND 502; NND-502; NND502

Networked: 98 relevant articles (26 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - luliconazole: 98

Experts

1.	Koga, Hiroyasu: 8 articles (08/2020 - 01/2006)
2.	Makimura, Koichi: 8 articles (08/2020 - 01/2006)
3.	Tsuboi, Ryoji: 8 articles (08/2020 - 01/2006)
4.	Yamaguchi, Hideyo: 8 articles (02/2019 - 01/2003)
5.	Nanjoh, Yasuko: 7 articles (08/2020 - 01/2006)
6.	Abastabar, Mahdi: 5 articles (06/2022 - 01/2018)
7.	Inagaki, Katsuhiro: 4 articles (03/2021 - 01/2017)
8.	Uchida, Katsuhisa: 4 articles (06/2006 - 01/2003)
9.	Sugiura, Keita: 3 articles (08/2022 - 01/2016)
10.	Tatsumi, Yoshiyuki: 3 articles (08/2022 - 01/2016)

Related Diseases

1.	Onychomycosis (Tinea Unguium) 06/24/2022 - "The objective of this study was to prepare and evaluate the luliconazole nail lacquer (LCZ-NL) for the effective treatment of onychomycosis. " 01/01/2023 - "Avoidance of sunlight and continuous application of luliconazole resolved the discoloration and were effective for the treatment of onychomycosis one year after the first visit." 12/01/2022 - "Using in vitro onychomycosis model, the effect of luliconazole on the morphology of the growing hyphae of Trichophyton mentagrophytes was investigated by scanning electron microscopy (SEM). " 12/01/2022 - "Effect of Topical Antifungal Luliconazole on Hyphal Morphology of Trichophyton mentagrophytes Grown on in vitro Onychomycosis Model." 06/24/2022 - "Luliconazole Nail Lacquer for the Treatment of Onychomycosis: Formulation, Characterization and In Vitro and Ex Vivo Evaluation."
2.	Tinea Pedis (Athlete's Foot) 01/01/2016 - "The results from Phase III trials show that luliconazole 1% cream applied once daily for 2 weeks successfully resolved the clinical signs and symptoms as well as eradicated the pathologic fungi, which cause tinea pedis. " 10/01/2014 - "Luliconazole cream 1% was safe and well-tolerated and demonstrated significantly greater efficacy than vehicle cream in patients with interdigital tinea pedis." 07/01/2014 - "This phase 3 study evaluated the safety and efficacy of luliconazole cream 1% in patients with tinea pedis. " 01/01/2015 - "Evidence from clinical trials in tinea pedis have shown once-daily application of luliconazole cream 1% for 14 days to be effective and well tolerated." 01/01/2015 - "In this article, we summarize the in vitro data, animal studies and clinical trial data relating to the use of topical luliconazole cream 1% in the treatment of tinea pedis. "
3.	Tinea (Ringworm) 09/01/2014 - "According to our meta-analysis, short-term treatment of luliconazole cream 1% can result in the complete clearance of dermatophytoses. " 06/01/2012 - "The dose-dependent therapeutic efficacy of topical luliconazole cream (0.02 to 1%), measured by macroscopic improvement of skin lesions and by fungal eradication as determined by a culture assay, was demonstrated using a tinea corporis model. " 11/01/2020 - "Luliconazole exhibits highest antifungal activity against Trichophyton spp. which are major causative agents of dermatophytosis. " 10/01/2020 - "Luliconazole is a new antifungal that was primarily used for the treatment of dermatophytosis. " 01/01/2016 - "Luliconazole would be the best-in-class drug for dermatophytosis in clinics. "
4.	Keratitis 10/01/2023 - "This suggests that luliconazole can be a novel therapeutic agent for human fungal keratitis." 10/01/2023 - "Antifungal Efficacy of Luliconazole in an Experimental Rabbit Model of Fungal Keratitis Caused by Fusarium solani." 02/01/2019 - "Efficacy of Luliconazole Against Broad-Range Filamentous Fungi Including Fusarium solani Species Complex Causing Fungal Keratitis." 09/01/2020 - "The increased antifungal activity of luliconazole observed in this study warrants further investigation for its potential as an antifungal drug for equine fungal keratitis." 09/26/2022 - "Development of a Luliconazole Nanoemulsion as a Prospective Ophthalmic Delivery System for the Treatment of Fungal Keratitis: In Vitro and In Vivo Evaluation."
5.	Infections 07/01/2020 - "In vitro antifungal activity of luliconazole against nondermatophytic moulds causing superficial infections was compared with that of five classes of 12 topical and systemic drugs. " 01/01/2018 - "Against the amastigote stage, luliconazole at a concentration of 0.07μM decreased the mean infection rate and the mean number of amastigotes per macrophage more effectively than MA (P<0.004) and KET (P<0.043), but there was no difference compared with AmB (P>0.05). " 01/01/2003 - "In the latter group, after confirming infection had been established, the infected animals were topically treated with the NND-502 cream once daily for one week. " 08/01/1999 - "fumigatus activity of oral NND-502 in a murine model of systemic infection was apparently superior to that of FCZ and ITZ in terms of prolonging survival. " 06/23/2014 - "Luliconazole cream (Luzu) for tinea infections."

Related Drugs and Biologics

1.	efinaconazole
2.	latoconazole (lanoconazole)
3.	imidazole
4.	Azoles
5.	Terbinafine (Lamisil)
6.	sertaconazole
7.	Emollients
8.	Natamycin (Pimaricin)
9.	Ketoconazole (Nizoral)
10.	Carbon Dioxide

Related Therapies and Procedures

1.	Gas Lasers
2.	Therapeutics
3.	Contraindications