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carbobenzoxy- alanyl- alanyl- borophenylalanyl

a tripeptide boronic acid-containing inhibitor of chymotrypsin

Also Known As:

DK120; benzyloxycarbonyl-Ala-Ala-borophe

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Boron Compounds: 91
  - carbobenzoxy-alanyl-alanyl-borophenylalanyl: 3
Organic Chemicals: 133
- Boron Compounds: 91
  - carbobenzoxy-alanyl-alanyl-borophenylalanyl: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - carbobenzoxy-alanyl-alanyl-borophenylalanyl: 3

Related Diseases

1.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 12/01/1994 - "Initial studies revealed that two inhibitors of serine proteases, N-1-tosylamide-2-phenylethylchloromethyl ketone and carbobenzoxy-Ala-Ala-borophe (DK120), suppressed tumor necrosis factor or ultraviolet (UV) light-induced DNA fragmentation in the U937 histiocytic lymphoma as well as UV light-induced DNA fragmentation in the BT-20 breast carcinoma, HL-60 myelocytic leukemia, and 3T3 fibroblasts. "
2.	Myeloid Leukemia (Leukemia, Myelocytic) 12/01/1994 - "Initial studies revealed that two inhibitors of serine proteases, N-1-tosylamide-2-phenylethylchloromethyl ketone and carbobenzoxy-Ala-Ala-borophe (DK120), suppressed tumor necrosis factor or ultraviolet (UV) light-induced DNA fragmentation in the U937 histiocytic lymphoma as well as UV light-induced DNA fragmentation in the BT-20 breast carcinoma, HL-60 myelocytic leukemia, and 3T3 fibroblasts. "
3.	Breast Neoplasms (Breast Cancer) 12/01/1994 - "Initial studies revealed that two inhibitors of serine proteases, N-1-tosylamide-2-phenylethylchloromethyl ketone and carbobenzoxy-Ala-Ala-borophe (DK120), suppressed tumor necrosis factor or ultraviolet (UV) light-induced DNA fragmentation in the U937 histiocytic lymphoma as well as UV light-induced DNA fragmentation in the BT-20 breast carcinoma, HL-60 myelocytic leukemia, and 3T3 fibroblasts. "
4.	Leukemia 04/28/1998 - "We showed that an inhibitor of AP24, DK120, could block DNA fragmentation induced in three leukemia cell lines (U937, HL-60, and CEM) by various DNA-damaging drugs including etoposide, camptothecin, chlorambucil, and the CC1065-related drug, YW201. " 10/06/1997 - "In three different leukemia cell lines, we showed that agents that directly (carbobenzoxy-Ala-Ala-borophe (DK120) or indirectly inhibit activation of AP24 (protein kinase inhibitors, basic fibroblast growth factor, tosylphenylalaninechloromethylketone, and caspase inhibitors) protected cells from apoptosis induced by TNF or UV light. "

Related Drugs and Biologics

1.	alanylalanine (Ala-Ala)
2.	Serine Proteases (Serine Protease)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Ketones
5.	Caspase Inhibitors
6.	Protein Kinase Inhibitors
7.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
8.	Etoposide (VP 16)
9.	DNA (Deoxyribonucleic Acid)
10.	Chlorambucil (Leukeran)