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FR 143430
a cytokine suppressive agent; structure given in first source
Also Known As:
2-(4-fluorophenyl)-4,5,6,7-tetrahydro-3-(4-pyridyl)pyrazolo(1,5-a)pyrimidine monohydrochloride; FR-143430; FR143430
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Pyrazoles: 61
FR 143430: 1
Pyrimidines: 510
FR 143430: 1
Related Diseases
1.
Neoplasms (Cancer)
01/01/1998 - "
Overall, this study demonstrated that the cachexia induced by colon26 was alleviated by the injection of FR143430 into the tumor in sufficient quantity, without any effect on tumor growth, suggesting the potential utility of cytokine suppressive agents e for the treatment of cancer cachexia.
"
01/01/1998 - "
Nevertheless, treatment with FR143430 (0.1 to lmg) into the tumor resulted in the attenuation of the reduction in body weight, food intake, epididymal fat and carcass weight, the decrease in the circulating levels of triglyceride and glucose, and the increase in the circulating levels of total cholesterol, non esterified free fatty acid (NEFA) and total protein, which were induced by the presence of the tumor.
"
2.
Cachexia
01/01/1998 - "
However, oral treatment with FR143430 failed to show an inhibitory effect on cachexia induction.
"
01/01/1998 - "
Overall, this study demonstrated that the cachexia induced by colon26 was alleviated by the injection of FR143430 into the tumor in sufficient quantity, without any effect on tumor growth, suggesting the potential utility of cytokine suppressive agents e for the treatment of cancer cachexia.
"
01/01/1998 - "
Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice.
"
01/01/1998 - "
In this study the effect of FR143430, (2-(4-fluorophenyl)-4, 5, 6, 7-tetrahydro-3-(4-pyridyl)pyrazolo[1, 5-a]pyrimidine monohydrochloride), an inhibitor of Interleukin-1 and Tumor necrosis factor-a (TNF- a), on adenocarcinoma colon26-induced cachexia was investigated in mice.
"
3.
Adenocarcinoma
01/01/1998 - "
Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice.
"
01/01/1998 - "
In this study the effect of FR143430, (2-(4-fluorophenyl)-4, 5, 6, 7-tetrahydro-3-(4-pyridyl)pyrazolo[1, 5-a]pyrimidine monohydrochloride), an inhibitor of Interleukin-1 and Tumor necrosis factor-a (TNF- a), on adenocarcinoma colon26-induced cachexia was investigated in mice.
"
4.
Body Weight (Weight, Body)
01/01/1998 - "
Nevertheless, treatment with FR143430 (0.1 to lmg) into the tumor resulted in the attenuation of the reduction in body weight, food intake, epididymal fat and carcass weight, the decrease in the circulating levels of triglyceride and glucose, and the increase in the circulating levels of total cholesterol, non esterified free fatty acid (NEFA) and total protein, which were induced by the presence of the tumor.
"
Related Drugs and Biologics
1.
Cytokines
2.
Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.
Interleukin-1 (Interleukin 1)
4.
pyrimidine
5.
Triglycerides (Triacylglycerol)
6.
Proteins (Proteins, Gene)
7.
Glucose (Dextrose)
8.
Nonesterified Fatty Acids (NEFA)
9.
Cholesterol