ultra-high molecular weight polyethylene (UHMWPE)

04/01/1998 - "Similarly, in tensile and fatigue tests of oxidized UHMWPE, there was a significant reduction in the ultimate tensile strength and in the fatigue resistance of specimens that had developed a subsurface band. "
09/01/2002 - "UHMWPE cable shows promise for this clinical application because of its greater tensile and fatigue strength. "
10/01/2011 - "This study evaluated the tradeoffs amongst fatigue crack propagation resistance, wear resistance, and oxidative stability in a wide variety of clinically-relevant cross-linked ultra-high molecular weight polyethylene. "
09/01/2006 - "The objective of this study was to demonstrate the applicability of the compliance method for fatigue crack propagation tests of UHMWPE. "
02/01/2006 - "This study was planned to evaluate the influence of UHMWPE remelting after irradiation on the material fatigue resistance. "

10/01/2015 - "This study aims to elucidate whether dendritic cells play a role in UHMWPE particle-induced osteolysis. "
01/01/2013 - "Further a UHMWPE-induced murine calvaria erosion model study was performed to assess the effects of PQQ on wear particle-induced osteolysis in vivo. "
08/01/2006 - "Cases of osteolysis from artificial discs are extremely rare, but hip and knee studies demonstrate the osteolytic potential and clinical concern of UHMWPE wear debris. "
02/01/2006 - "In conclusion, this study provides the evidence that EM inhibits the UHMWPE particles-induced inflammatory osteolysis in a murine model, and represents a promising therapeutic candidate for the prevention and treatment of AL."
10/01/2015 - "Osteolysis induced by the UHMWPE wear particles is one of the main causes of replacement failure. "

08/01/2006 - "In conclusion, this study provides the evidence that UHMWPE particles induce strong inflammatory responses, but not associated with osteoclastic bone resorption in RANK(-/-) mice. "
09/01/2014 - "There was a statistically significant difference between virgin (12.2%±8%) and VE-UHMWPE (3%±1.4%) groups in regards to bone resorption (P=0.005) and inflammatory fibrous tissue overlaying the calvaria (0.48 vs. 0.20, P<0.0001). "
05/01/2013 - "However, the effects of modifying monomer size, crosslink density, and antioxidant incorporation on UHMWPE particle-induced osteoclastic bone resorption and coupled osteoblastic bone formation have never been tested. "
08/01/2006 - "This indicates that RANK signaling is essential for UHMWPE particle-induced osteoclastic bone resorption, but does not participate in UHMWPE particle-induced inflammatory response."
08/01/2006 - "Consistent with the lack of osteoclastic activity shown by TRAP staining, no significant UHMWPE particle-induced bone resorption was found in RANK(-/-) mice. "

09/01/1998 - "Although T cells are not directly involved in UHMWPE particle induced inflammation, as shown by the T cell activation assays, the histological data from the mice studies clearly show differences in the amplitude of inflammation from animals with and without functional T cells. "
08/01/2014 - "The observations support the hypothesis that the activation of the CX3CR1 chemokine pathway contributes to the severity of UHMWPE particle-induced tissue inflammation, and suggests that CX3CR1 signaling is involved in the recruitment of monocytes to the wear debris-containing inflammatory tissues. "
08/01/2014 - "UHMWPE-induced inflammation was significantly mitigated in CX3CR1(-/-) mice, as manifested by reduction of tissue inflammation (pouch thickness and cell density), inflammatory cytokine production (IL-1ß and TNFα) and macrophage accumulation. "
08/01/2014 - "Results showed that UHMWPE stimulation induced strong pouch tissue inflammation in CX3CR1(+/+) mice, as manifested by inflammatory cellular infiltration (mainly macrophages), pouch tissue proliferation, and increased gene expression of IL-1ß and TNFα. "
01/01/2013 - "However, in the soft wire group, both the surface of the greater trochanter under the fixation material and the penetration area around the fixation material showed an increased tendency toward a biological reaction, including inflammation and granulation tissue formation, as compared to the UHMWPE fiber cable group. "

02/01/2013 - "It is observed that the toughness, ultimate stress, fracture strain, and yield stress of medical grade UHMWPE were enhanced by 176, 93, 70, and 44%, respectively at an optimum concentration of 2 wt% MWCNTs reinforcement. "
09/01/2010 - "Such an implant has the potential of decreasing risk of fatigue fracture of total joint implants as well as expanding the use of UHMWPE to younger and more active patients."
10/01/2005 - "Only gamma-irradiated UHMWPE specimens resulted in severe fatigue fractures. "
10/01/2000 - "However, UHMWPE components undergo cyclic loading during use and at least two wear damage modes (pitting and delamination) are thought to be associated with the fatigue fracture properties of UHMWPE. "
01/01/1995 - "Wear damage to the articulating surfaces of total joint components made of ultra high molecular weight polyethylene is associated with a fatigue fracture mechanism, despite the fact that these surfaces are subjected to primarily compressive and compressive-tensile cyclic stresses. "