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1-methyl-3-propyl-7-butylxanthine

structure in first source

Also Known As:

XT-77

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - 1-methyl-3-propyl-7-butylxanthine: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        1-methyl-3-propyl-7-butylxanthine: 3

Experts

1.	Egawa, Y: 1 article (06/2000)
2.	Miyamoto, K: 1 article (06/2000)
3.	Sadzuka, Y: 1 article (06/2000)
4.	Sawanishi, H: 1 article (06/2000)
5.	Sonobe, T: 1 article (06/2000)
6.	Sugiyama, T: 1 article (06/2000)

Related Diseases

1.	Leukemia P388 04/26/1999 - "Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia." 06/01/2000 - "The effects of 1-methyl-3-propyl-7-butylxanthine (MPBX), a xanthine derivative, on idarubicin (IDA)-induced antitumor activity against P388 leukemia cells (P388) and bone marrow suppression were examined. " 04/26/1999 - "The effects of 1-methyl-3-propyl-7-butylxanthine (MPBX), a xanthine derivative, on doxorubicin (DOX)-induced antitumor activity against DOX-sensitive P388 leukemia (P388) and DOX-resistant P388 leukemia (P388/DOX) have been examined. "
2.	Drug-Related Side Effects and Adverse Reactions 02/01/1998 - "Thus, the combination of XT-77 with adriamycin not only increased the antitumor activity of adriamycin, but also decreased the adverse drug reactions." 02/01/1998 - "Furthermore, XT-77 reduced the adverse drug reactions of adriamycin by decreasing the adriamycin concentrations in the heart and the liver. "
3.	Neoplasms (Cancer) 02/01/1998 - "1-Methyl-3-propyl-7-butylxanthine (XT-77), which had the greatest inhibitory effect on adriamycin efflux in vitro among the compounds tested, potentiated adriamycin-induced antitumor activity by causing an increase of adriamycin concentration in the tumor in vitro. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Xanthine
3.	Idarubicin (4 Demethoxydaunorubicin)