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AC133 antigen (prominin)

Subscribe to New Research on AC133 antigen

hematopoietic stem cell antigen; RefSeq NM_006017 (human); NM_008935 (mouse); NM_021751 (rat)

Also Known As:

prominin; AC 133 antigen; AC133 antigen, human; AC133 protein, human; AC133 protein, mouse; AC133-1 antigen; AC133-2 antigen; AC141 antigen; CD133 antigen; CD133 antigen, rat; CD133 protein, human; CD133 protein, mouse; PROM1 protein, human; PROML1; Prom1 protein, mouse; Prom1 protein, rat; fudenine; fudenine protein, rat; prominin 1 protein, human; prominin 1 protein, mouse; prominin 1 protein, rat; prominin-1; prominin-like PROML1

Networked: 109 relevant articles (1 outcomes, 13 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Corbeil, Denis: 13 articles (01/2014 - 03/2003)
2.	Huttner, Wieland B: 8 articles (01/2014 - 03/2003)
3.	Fargeas, Christine A: 7 articles (01/2014 - 03/2003)
4.	Marzesco, Anne-Marie: 4 articles (01/2014 - 01/2005)
5.	Janich, Peggy: 4 articles (01/2014 - 04/2007)
6.	Blyszczuk, Przemyslaw: 4 articles (01/2011 - 11/2008)
7.	Eriksson, Urs: 4 articles (01/2011 - 11/2008)
8.	Kania, Gabriela: 4 articles (01/2011 - 11/2008)
9.	Moore, Anthony T: 3 articles (01/2015 - 08/2008)
10.	Karbanová, Jana: 3 articles (01/2014 - 02/2011)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 08/01/2010 - "CD133 antigen has been used to identify cancer stem cells in several solid tumor types, including hepatocellular carcinomas (HCCs). " 01/01/2013 - "CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival." 01/01/2012 - "The results were further validated by RT-PCR, western blot, flow cytometry or immunofluorescent staining which revealed that prominin-1, annexin A1, annexin A3, transgelin, creatine kinase B, vimentin, and EpCAM were indeed highly expressed in the CD133-positive hepatoma cells. "
2.	Neoplasms (Cancer) 01/01/2013 - "In this introductory chapter, we attempted to review 15 years of prominin-1 study, focusing on its unique protein characteristics across species and the recent developments regarding its cell biology that may shed new light on its intriguing involvement in defining cancer-initiating cells." 01/01/2014 - "Collectively, our findings bring new insights into the biochemistry and trafficking of prominin-1 as well as its immunohistochemical profile in certain types of salivary gland tumors and inflammatory diseases. " 09/01/2013 - "CD133 (Prominin-1/AC133) is generally treated as a cell surface marker found on multipotent stem cells and tumor stem-like cells, and its biological function remains debated. " 06/01/2013 - "Prominin-1 and its role in tumor progression and assessment of clinical prognosis in systemic malignancies." 05/10/2013 - "Prominin-1 is of great interest as a marker for stem and cancer cells, while Prominin-2 (Prom2) is reportedly restricted to epithelial cells. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "The electronic and manual searches were performed through the database of Pubmed, Medline, Web of Science, Scopus, and Chinese CNKI (from January 1, 1982 to January 1, 2014) for titles and abstracts by using the following keywords: "CD133", "ac133" or "Prominin-1", and "lung cancer" to identify the studies eligible for our analysis. " 07/01/2011 - "The objective of the current study was to investigate the effect of the strong STAT3 inhibitor, cucurbitacin I, in prominin-1 (CD133)-positive lung cancer cells. " 09/10/2013 - "The stem cell-like resistance to injury and proliferative potentials of bronchioalveolar stem cells (BASCs) and alveolar epithelial type II cells (AEC2), as well as cells that express the cancer stem cell marker glycoprotein prominin-1 (CD133) or markers for side populations make them potential reservoirs of lung cancer stem cells. " 01/01/2014 - "This study investigated gene mutations in a Han Chinese family of lung cancer using the whole genome exome sequencing and subsequent Sanger sequencing validation and then confirmed alteration of prominin 1(PROM1) and cyclic AMP-response element binding protein-regulated transcription co-activator2 (CRTC2) in blood samples of 343 sporadic lung cancer patients vs. 280 healthy controls as well as in 200 pairs of lung cancer and the corresponding normal tissues using PCR-restriction fragment length polymorphism and directed DNA sequencing of PCR products. "
4.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2014 - "In this study, CSCs were isolated from colorectal cancer cells using PROM1/CD133 (prominin 1) expression, which is a surface marker commonly found on stem cells of various tissues. " 02/15/2013 - "Despite the well recognized expression of the cell surface markers cluster of differentiation 44 (homing cell adhesion molecule) and CD133 (Prominin 1) on human colorectal cancer stem cells (CCSCs), these molecules do not appear to be effective targets for stem cell-directed therapies. " 07/01/2012 - "The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. " 01/01/2010 - "O'Brien and Ricci et al. have proved that in primary colorectal tumors there are colorectal tumor stem cells (initiating cells) which are marked by CD133 antigen. " 09/01/2009 - "The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. "
5.	Retinal Degeneration 01/01/2000 - "In the present study, molecular genetic analyses of a pedigree segregating for autosomal recessive retinal degeneration indicated that the affected individuals were homozygous for a nucleotide 1878 deletion in PROML1. " 01/01/2014 - "Similar to crumbs mutant PRCs, PRCs devoid of prominin or eyes shut undergo light-dependent retinal degeneration. " 01/01/2013 - "Clinically, mutations in the PROM1 gene are associated with various forms of retinal degeneration, which are mimicked in genetically modified mice carrying either a null allele or mutated form of PROMININ-1. " 01/01/2012 - "Mutations in the prominin-1 gene cause retinal degeneration in humans. " 01/01/2011 - "Besides being a marker of various somatic stem cells in mammals, prominin-1 (CD133) plays a role in maintaining the photoreceptor integrity since mutations in the PROM1 gene are linked with retinal degeneration. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	nestin (nestin protein)
3.	Antigens
4.	Osteopontin
5.	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)
6.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
7.	Proteins (Proteins, Gene)
8.	DNA (Deoxyribonucleic Acid)
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
10.	cucurbitacin I

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy