SC-1 monoclonal antibody

tested for treatment of stomach cancer; induces tumor- specific apoptosis in vivo in mice; amino acid sequences of VH3, D, and JH segments given in first source

Also Known As:

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hensel, F: 3 articles (11/2001 - 01/2000)
2.	Müller-Hermelink, H K: 3 articles (11/2001 - 01/2000)
3.	Vollmers, H P: 3 articles (11/2001 - 01/2000)
4.	Brändlein, S: 2 articles (11/2001 - 01/2001)
5.	Hermann, R: 2 articles (11/2001 - 01/2001)
6.	Geis, S: 1 article (11/2001)
7.	Krenn, V: 1 article (11/2001)
8.	Schmausser, B: 1 article (11/2001)
9.	Keppler, M: 1 article (01/2001)
10.	Müller, E C: 1 article (01/2001)

Related Diseases

1.	Carcinoma (Carcinomatosis) 10/15/1999 - "The human monoclonal antibody SC-1 induces apoptosis of stomach carcinoma cells and is currently used in a clinical Phase II trial. " 08/15/1995 - "The human monoclonal antibody SC-1 described here inhibited growth of stomach carcinoma cells in vitro and in vivo by inducing apoptosis, and may, therefore, be valuable for treating patients with stomach carcinoma." 05/01/1989 - "The human monoclonal antibody SC-1 was found to selectively react with cultured cells isolated from autologous and allogeneic stomach carcinoma patients, and with cryostat sections of the primary tumors. " 01/01/2000 - "The human monoclonal antibody SC-1 was isolated from a patient with a diffuse-type adenocarcinoma of the stomach and induces apoptosis of stomach carcinoma cells by binding a stomach-carcinoma-associated isoform of CD55/DAF-B. "
2.	Neoplasms (Cancer) 05/01/1989 - "The human monoclonal antibody SC-1 was found to selectively react with cultured cells isolated from autologous and allogeneic stomach carcinoma patients, and with cryostat sections of the primary tumors. " 02/01/1997 - "Immunohistochemical studies were performed on frozen sections of tumor tissue using human monoclonal antibody SC-1 and murine monoclonal antibodies Fas and p53, followed by peroxidase-coupled second antibodies. " 01/01/2001 - "During tumor specific apoptosis, induced by the human monoclonal antibody SC-1, tyrosine phosphorylation and serine dephosphorylation of several proteins is observed. "
3.	Adenocarcinoma 11/01/2001 - "The human monoclonal antibody SC-1 was isolated from a patient with a diffuse-type adenocarcinoma of the stomach using somatic cell hybridization. " 01/01/2000 - "The human monoclonal antibody SC-1 was isolated from a patient with a diffuse-type adenocarcinoma of the stomach and induces apoptosis of stomach carcinoma cells by binding a stomach-carcinoma-associated isoform of CD55/DAF-B. "
4.	Signet Ring Cell Carcinoma 08/15/1995 - "The human monoclonal antibody SC-1 was isolated from a patient with a signet ring cell carcinoma of the stomach by fusion of spleen lymphocytes to the heteromyeloma SPM4-0. "

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5.	Tyrosine (L-Tyrosine)
6.	Serine (L-Serine)
7.	Proteins (Proteins, Gene)