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8- hydroxy- 3- (n- propyl)- 1,2,3a,4,5,9b- hexahydro- 1H- benz(e)indole

structure in first source

Also Known As:

cis-8-OH-PBZI

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 8-hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz(e)indole: 2

Experts

1.	Andersen, Maibritt B: 1 article (08/2004)
2.	Malik, Peter: 1 article (08/2004)
3.	Peacock, Linda: 1 article (08/2004)

Related Diseases

1.	Dyskinesias (Dyskinesia) 08/01/2004 - "Eight Cebus monkeys displaying mild to severe TD due to previous chronic exposure to DA D2 antagonists were acutely injected with SKF 81297 (DA D1 agonist) 0.3 and 0.6 mg/kg, pramipexole (DA D3>D2 agonist) 0.025-0.1 mg/kg, CIS-8-OH-PBZI (DA D3 agonist) 5-10 mg/kg and SB-27701-A (DA D3 antagonist) 1-5 mg/kg and rated for oral dyskinesia. "
2.	Catalepsy 01/26/1998 - "Moreover, cis-8-OH-PBZI inhibited conditioned avoidance responding in rats, a preclinical test indicative of antipsychotic efficacy, at doses which did not induce catalepsy. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Pramipexole (Mirapex)
3.	SK&F 81297