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methyl lexitropsin

structure in first source

Also Known As:

Me-Lex

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Netropsin: 26
      - methyl lexitropsin: 8

Experts

1.	Gold, Barry: 5 articles (07/2010 - 03/2002)
2.	Gold, B: 3 articles (06/2010 - 08/2001)
3.	Fronza, Gilberto: 2 articles (07/2010 - 03/2008)
4.	Inga, Alberto: 2 articles (07/2010 - 03/2008)
5.	Menichini, Paola: 2 articles (07/2010 - 03/2008)
6.	Monti, Paola: 2 articles (07/2010 - 03/2008)
7.	Perfumo, Chiara: 2 articles (07/2010 - 03/2008)
8.	Russo, Debora: 2 articles (07/2010 - 03/2008)
9.	Graziani, G: 2 articles (06/2010 - 08/2001)
10.	Tentori, L: 2 articles (06/2010 - 08/2001)

Related Diseases

1.	Xeroderma Pigmentosum (Kaposi's Disease) 06/03/2004 - "The present study examines the role of the BER enzyme 3-alkyladenine DNA glycosylase (AAG) and the NER protein xeroderma pigmentosum group A (XPA) in protecting cerebellar neurons and astrocytes from chloroacetaldehyde (CAA) or the alkylating agent 3-methyllexitropsin (Me-Lex), which produce ethenobases or 3-methyladenine (3-MeA), respectively. "
2.	Leukemia 02/01/2005 - "In the present study, we show that MeOSO(2) (CH(2))(2)-lexitropsin (Me-Lex), a compound generating almost exclusively N3-methyladenine (>99%), provoked a burst of poly(ADP-ribosylation) and loss of mitochondrial membrane potential in leukemia cells. "
3.	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 03/01/2008 - "To examine the contribution of translesion synthesis (TLS) DNA polymerases in the bypass of Me-lex-induced lesions, the REV3 and REV1 genes were independently deleted in the parental yeast strain and in different DNA repair-deficient derivatives: the nucleotide excision repair (NER)-deficient rad14, and the BER-deficient mag1 or apn1apn2 strains. "
4.	Genomic Instability 07/01/2010 - "These results indicate that XRCC1 deficiency can lead to genomic instability even in the absence of an exogenous genotoxic insult and low levels of Me-lex-induced lesions, i.e., 3-mA and/or a BER intermediate, can exacerbate this instability." 07/01/2010 - "XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine."
5.	Neoplasms (Cancer) 03/01/2002 - "When concentrations of PARP-1 inhibitors (25 microM NU and 4 m M AB) that produced a twofold increase in Me-Lex cytotoxicity in tumor cells were compared, NU induced a less-pronounced increase in apoptosis in PBL treated with Me-Lex; (c) Me-Lex at concentrations that allowed cytogenetic analysis did not induce a significant number of SCE; (d) PARP-1 inhibitors provoked a dose-dependent increase in SCE, but 25 microM NU was devoid of genotoxic effects and did not significantly increase SCE in PBL treated with Me-Lex. " 03/01/2002 - "However, tumor cells with high MPG activity can be rendered susceptible to Me-Lex using poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. "

Related Drugs and Biologics

1.	Alkylating Agents
2.	N3-methyladenine
3.	3-methyladenine
4.	DNA Glycosylases (DNA Glycosylase)
5.	Proteins (Proteins, Gene)
6.	Enzymes
7.	chloroacetaldehyde
8.	methyl lexitropsin
9.	Methyltransferases
10.	DNA-Directed DNA Polymerase (Polymerases, DNA)

Related Therapies and Procedures

1.	Therapeutics