cytochrome P-450 CYP71E1 (sorghum)

an A-type cytochrome P-450 that catalyzes the conversion of p-hydroxyphenylacetaldoxime to p-hydroxymandelonitrile; amino acid sequence in first source; GenBank AF029858

Also Known As:

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bak, Søren: 1 article (11/2015)
2.	Blomstedt, Cecilia K: 1 article (11/2015)
3.	Clausen, Mette: 1 article (11/2015)
4.	Gleadow, Roslyn M: 1 article (11/2015)
5.	Jørgensen, Kirsten: 1 article (11/2015)
6.	Kannangara, Rubini M: 1 article (11/2015)
7.	Motawie, Mohammed S: 1 article (11/2015)
8.	Møller, Birger Lindberg: 1 article (11/2015)
9.	Olsen, Carl E: 1 article (11/2015)

Related Diseases

1.

Dehydration (Water Stress) 02/01/1998 - "coli is only able to support CYP71E1 in the dehydration reaction, and not in the subsequent C-hydroxylation reaction. " 03/01/1999 - "CYP71E1 catalyzes an unusual dehydration reaction of an oxime to the corresponding nitrile which subsequently is C-hydroxylated. " 11/01/2015 - "In this study we used microsomes prepared from wild-type and mutant sorghum or transiently transformed Nicotiana benthamiana to demonstrate that CYP79A1 catalyzes conversion of tyrosine to (E)-p-hydroxyphenylacetaldoxime whereas CYP71E1 catalyzes conversion of (E)-p-hydroxyphenylacetaldoxime into the corresponding geometrical Z-isomer as required for its dehydration into a nitrile, the next intermediate in cyanogenic glucoside synthesis. " 02/01/1998 - "In accordance to the proposed pathway for dhurrin biosynthesis CYP71E1 catalyses the dehydration of the oxime to the corresponding nitrile, followed by a C-hydroxylation of the nitrile to produce p-hydroxymandelonitrile. "

Related Drugs and Biologics

1.	Nitriles
2.	Tyrosine (L-Tyrosine)
3.	Glucosides
4.	Oximes
5.	dhurrin