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proteasome maturation protein

Subscribe to New Research on proteasome maturation protein

required for 20S proteasome maturation

Also Known As:

POMP protein, human; Pomp protein, mouse; UMP1 protein, S cerevisiae; YBR173C protein, S cerevisiae; proteasome maturation protein, human; proteasome maturation protein, mouse

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Molecular Chaperones: 904
    - proteasome maturation protein: 3

Experts

1.	Orlowski, Robert Z: 1 article (12/2015)
2.	Kuiatse, Isere: 1 article (12/2015)
3.	Fu, Jinxiang: 1 article (12/2015)
4.	Wang, Hua: 1 article (12/2015)
5.	Li, Yali: 1 article (12/2015)
6.	Chen, Ping: 1 article (12/2015)
7.	Zhang, Xingding: 1 article (12/2015)
8.	Ge, Xueping: 1 article (12/2015)
9.	Wang, Huihan: 1 article (12/2015)
10.	Li, Bingzong: 1 article (12/2015)

Related Diseases

1.	Multiple Myeloma 12/11/2015 - "The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma."
2.	Keratosis 01/01/2012 - "Keratosis linearis with ichthyosis congenita and keratoderma (KLICK) is an autosomal recessive skin disorder associated with a single-nucleotide deletion in the 5'untranslated region of the proteasome maturation protein (POMP) gene. "
3.	Ichthyosis (Xeroderma) 01/01/2012 - "Keratosis linearis with ichthyosis congenita and keratoderma (KLICK) is an autosomal recessive skin disorder associated with a single-nucleotide deletion in the 5'untranslated region of the proteasome maturation protein (POMP) gene. "
4.	Burkitt Lymphoma (Burkitt's Lymphoma) 01/01/2008 - "Here we show that continuous inhibition of proteasomal chymotrypsin-like peptidase activity by the proteasome inhibitor bortezomib induces in human Namalwa Burkitt lymphoma cells increased de novo biogenesis of proteasomes accompanied by increased expression of the proteasome maturation protein POMP, increased expression of 19S-20S-19S proteasomes, and abrogation of expression of beta 1i, beta 2i and beta 5i immunosubunits and PA28 in favor of increased expression of constitutive proteolytic beta1, beta2 and beta 5 subunits and 19S regulatory complexes. "

Related Drugs and Biologics

1.	bortezomib (Velcade)
2.	Proteasome Endopeptidase Complex (Proteasome)
3.	5' Untranslated Regions (5' UTR)
4.	Chymotrypsin