mebudipine

11/30/2016 - "In addition, mebudipine significantly reduced the severity of arrhythmias in comparison with control hearts.  Moreover, the drug group demonstrated marked improvement in edema and infiltration of inflammatory cells especially with regard to the degree of myonecrosis and cell lysis.Mebudipine"

11/30/2016 - "Therefore, this study was aimed to investigate the effects of mebudipine on myocardial arrhythmias and tissue injury induced by ischemia/reperfusion injury in isolated rat hearts. "
11/30/2016 - "The effects of mebudipine on myocardial arrhythmia induced by ischemia-reperfusion injury in isolated rat heart."
11/01/2011 - "Our results indicate that mebudipine reduced the intensity of myocardial ischaemia-reperfusion injury, and that activation of the myocardial nitric oxide system played an important role in this regard."
11/01/2011 - "The effect of mebudipine on cardiac function and activity of the myocardial nitric oxide system in ischaemia-reperfusion injury in rats."
12/01/2012 - "Our results showed that mebudipine may have antioxidant activity against myocardial ischemia-reperfusion injury since it decreased oxidative stress by enhancing the enzymatic antioxidant defense and inhibiting the lipid peroxidation. "

01/01/2015 - "In previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. "
08/01/2004 - "With regard to the above findings, mebudipine might have a selective and protective calcium channel blocking effect in ischemic regions (ischemia-selectivity), and the potential to be used in cardiovascular diseases without causing harmful effects such as reflex tachycardia and heart failure which have sometimes been seen with the older agents."

12/01/2012 - "Our results showed that mebudipine may have antioxidant activity against myocardial ischemia-reperfusion injury since it decreased oxidative stress by enhancing the enzymatic antioxidant defense and inhibiting the lipid peroxidation. "
12/01/2012 - "The aim of this study was to investigate the effect of mebudipine, a new dihydropyridine calcium channel blocker, on lipid peroxidation and antioxidant enzymes in myocardial ischemia-reperfusion injury. "

11/30/2016 - "Male Wistar rats (250‑300g) were randomly divided to Sham group (without ischemia), control group (ischemia without drug), drug group (ischemia with mebudipine 0.1nM) and vehicle group (ischemia with ethanol 0.01%). "
12/01/2012 - "Ischemic groups were received 30 min global ischemia and 120 min reperfusion and the mebudipine and vehicle groups received mebudipine (0.1 nM) or ethanol (0.01%)-enriched solution 25 min before global ischemia. "
08/01/2004 - "With regard to the above findings, mebudipine might have a selective and protective calcium channel blocking effect in ischemic regions (ischemia-selectivity), and the potential to be used in cardiovascular diseases without causing harmful effects such as reflex tachycardia and heart failure which have sometimes been seen with the older agents."