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pregnane X receptor

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orphan nuclear receptor activated by pregnanes and other compounds including hyperforin, rifampicin & mevastatin; functions as a TRANSCRIPTION FACTOR to induce P450 3A4
Also Known As:
NR1I2 protein, human; Nr1i2 protein, mouse; Nr1i2 protein, rat; PXR receptor; SXR receptor; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1, group I, member 2 protein, human; nuclear receptor subfamily 1, group I, member 2 protein, mouse; nuclear receptor subfamily 1, group I, member 2, rat; steroid X receptor; steroid and xenobiotic receptor (SXR)
Networked: 171 relevant articles (8 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Mani, Sridhar: 10 articles (02/2015 - 09/2005)
2. Chen, Taosheng: 7 articles (05/2015 - 11/2008)
3. Gonzalez, Frank J: 7 articles (12/2014 - 04/2007)
4. Blumberg, Bruce: 6 articles (06/2011 - 01/2006)
5. Zhou, Changcheng: 5 articles (05/2015 - 06/2006)
6. Dou, Wei: 5 articles (02/2015 - 01/2012)
7. Li, Hao: 5 articles (09/2014 - 08/2011)
8. Venkatesh, Madhukumar: 5 articles (05/2013 - 09/2008)
9. Wang, Hongwei: 4 articles (01/2012 - 09/2008)
10. Chen, Yakun: 4 articles (09/2010 - 11/2007)

Related Diseases

1. Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
2. Asthma (Bronchial Asthma)
01/01/2013 - "Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by CYP3A enzymes in the lung.  CYP3A4, 3A5, and 3A7 enzymes metabolize glucocorticoids, which in turn induce CYP3A genes.  However, the mechanism of CYP3A5 mRNA regulation by glucocorticoids in lung cells has not been determined.  In hepatocytes, glucocorticoids bind to the glucocorticoid receptor (GR), which induces the expression of the constitutive androstane receptor or pregnane X receptor; both of which bind to the retinoid X receptor alpha, leading to the induction of CYP3A4, 3A5, and 3A7.  There is also evidence to suggest a direct induction of CYP3A5 by GR activation in liver cells. "
01/01/2013 - "Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by CYP3A enzymes in the lung.  CYP3A4, 3A5, and 3A7 enzymes metabolize glucocorticoids, which in turn induce CYP3A genes.  However, the mechanism of CYP3A5 mRNA regulation by glucocorticoids in lung cells has not been determined.  In hepatocytes, glucocorticoids bind to the glucocorticoid receptor (GR), which induces the expression of the constitutive androstane receptor or pregnane X receptor; both of which bind to the retinoid X receptor alpha, leading to the induction of CYP3A4, 3A5, and 3A7.  There is also evidence to suggest a direct induction of CYP3A5 by GR activation in liver cells. "
3. Inflammation
4. Cholestasis
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. constitutive androstane receptor
3. Cytochrome P-450 CYP3A
4. Enzymes
5. Retinoid X Receptor alpha
6. Glucocorticoid Receptors (Glucocorticoid Receptor)
7. Glucocorticoids
8. NF-kappa B (NF-kB)
9. Cytochrome P-450 Enzyme System (Cytochrome P450)
10. rifaximin (L 105)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Transplants (Transplant)
3. Adjuvant Chemotherapy
4. Kidney Transplantation
5. Heterologous Transplantation (Xenotransplantation)