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MCNO regimen

a chemotherapy regimen consisting of above cpds; for treatment of either metastatic or locally advanced transitional cell carcinoma of the bladder

Also Known As:

MCNO protocol

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MCNO regimen: 1
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MCNO regimen: 1
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MCNO regimen: 1
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Vinca Alkaloids: 463
        Vincristine: 9251
        MCNO regimen: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
Organic Chemicals: 133
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - Anthrones: 12
      - Anthraquinones: 788
        Mitoxantrone: 2907
        MCNO regimen: 1

Related Diseases

1.	Neoplasms (Cancer) 03/01/1998 - "The MCNO regimen appears to have a lower efficacy than that obtained with cisplatin-based regimens for the treatment of metastatic disease and rather similar efficacy for the treatment of locally advanced urothelial-cell cancer. "
2.	Transitional Cell Carcinoma 03/01/1998 - "Forty-four patients with either metastatic or locally advanced transitional cell carcinoma of the bladder were treated with the MCNO regimen (methotrexate 300 mg/m2 in 1,000 ml normal saline as a 4-hour infusion on days 1 and 14 with leucovorin rescue 15 mg 6-hourly for 6 doses; carboplatin 300 mg/m2 in 250 ml 5% distilled water as a 1-hour infusion on day 1; mitoxantrone (Novantrone) 10 mg/m2 in 100 ml 5% distilled water as a 30-min infusion on day 1, and vincristine (Oncovin) 1 mg/m2 as an intravenous bolus on days 1 and 14. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Carboplatin (JM8)
3.	Vincristine (Oncovin)
4.	Mitoxantrone (Novantrone)
5.	Methotrexate (Mexate)
6.	Leucovorin (Folinic Acid)
7.	Saline Solution