Somatostatin

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

Also Known As:

Somatotropin Release-Inhibiting Factor; Somatotropin Release Inhibiting Hormone; SRIH-14; Somatofalk; Somatostatin, Cyclic; Stilamin; Somatostatin 14; Somatotropin Release Inhibiting Factor; Cyclic Somatostatin; Somatostatin-14; Somatotropin Release-Inhibiting Hormone

Pharmalogical Action Categories:

Hormones

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Somatostatin: 8960
    - Hypothalamic Hormones: 68
      - Pituitary Hormone Release Inhibiting Hormones
        Somatostatin: 8960
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Hypothalamic Hormones: 68
        Pituitary Hormone Release Inhibiting Hormones
        Somatostatin: 8960
- Peptides: 82426
  - Neuropeptides: 6772
    - Hypothalamic Hormones: 68
      - Pituitary Hormone Release Inhibiting Hormones
        Somatostatin: 8960
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Somatostatin: 8960
    - Hypothalamic Hormones: 68
      - Pituitary Hormone Release Inhibiting Hormones
        Somatostatin: 8960

CH 288

Bio-Agent Context: Research Results