laminin 8

08/01/2004 - "In the current study, the authors studied glial tumors of different grades in an attempt to correlate laminin-8 expression with tumor recurrence and patient survival. "
05/01/2014 - "It was previously shown that high levels of laminin-8 expression were a predictor of tumor recurrence and patient survival. "
08/01/2004 - "Overexpression of laminin-8 in GBM was found to be associated with a statistically significant shorter time to tumor recurrence (P < 0.0002) and a decreased patient survival time (P < 0.015). "
08/01/2004 - "Association between laminin-8 and glial tumor grade, recurrence, and patient survival."
08/01/2004 - "The data suggest that laminin-8, which may facilitate tumor invasion, contributes to tumor regrowth after therapy. "

05/01/2014 - "This study investigated the mechanism of regulation of LAMB1, which encodes the β1 chain of laminin-8, in glioma cells lines and in a mouse model of GBM. "
05/01/2014 - "It is thus important to elucidate the mechanism by which laminin-8 expression is regulated and determine how this contributes to glioma progression. "
10/20/2005 - "These results suggest that mainly laminin-8 is essential for the invasive activity of human glioma cells; thus, a novel therapeutic strategy could target this molecule to treat patients with malignant glioma."
10/01/2003 - "Moreover, increase of the alpha4 chain-containing laminin-8 correlated with poor prognosis for patients with brain gliomas. "
10/01/2003 - "Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro."

02/01/2006 - "These studies suggest that laminin-8 overexpression may prove to be a useful method to engineer HDMECs to promote angiogenesis and wound repair."

01/01/2006 - "These data suggest that laminin-8 may be important for glioblastoma angiogenesis. "
01/01/2006 - "Increased laminin-8 correlated with shorter glioblastoma recurrence time and poor patient survival making it a potential marker for glioblastoma diagnostics and prediction of disease outcome. "
01/01/2006 - "We have previously shown that laminin-8, a vascular basement membrane component, was overexpressed in human glioblastomas multiforme and their adjacent tissues compared to normal brain. "
01/01/2006 - "Polycefin efficiently inhibited the expression of both laminin-8 chains by cultured glioblastoma cells. "
08/01/2004 - "One of these laminins, laminin-8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines. "

06/15/2004 - "Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice."
01/01/2005 - "In contrast, laminin beta1 chain (a constituent of laminin-8) was typically found in vessel walls of carcinomas and their metastases but not in those of normal breast. "
01/01/2005 - "Forty-five clinical samples of breast tissues including normal breast, ductal carcinomas in situ, invasive ductal carcinomas, and their metastases to the brain were compared using Western blot analysis and immunohistochemistry for various chains of laminin, in particular laminin-8 and laminin-9. "