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12-nitrocamptothecin

is a synthetic structural analogue of comptothecin

Also Known As:

12-NC; 12-Nitro-camptothecin

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Camptothecin: 2033
    - 12-nitrocamptothecin: 1

Related Diseases

1.

Neoplasms (Cancer)

01/01/1997 - "These results suggest that higher accumulation of 9-NC in tumor tissues than of 12-NC may contribute to the more potent chemotherapeutic activity of the former agent. "
01/01/1997 - "dose of 9-NC was higher than that in the tumors of i.v.-treated animals and was also higher than that in tumors of animals treated with 12-NC. "
01/01/1997 - "As part of our investigation of the pharmacology and the mechanism of tumor inhibition of these compounds, we examined the effect of route of administration on the distribution of tritium-labeled 9-NC and 12-NC, an active and a poor chemotherapeutic agent, respectively. "
01/01/1997 - "9-Nitrocamptothecin (9-NC) and 12-nitrocamptothecin (12-NC) are synthetic structural analogues of camptothecin (CPT) which have been prepared to explore the structure/activity relationship of this group of compounds against a wide variety of experimental tumors. "

Related Drugs and Biologics

1.	Tritium
2.	Camptothecin
3.	rubitecan
4.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole