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superoxide dismutase 1

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mutant SOD-1 is associated with familial ALS; see also SOD1 G93A protein; RefSeq NM_000454 (human), NM_017050 (rat), NM_011434 (mouse)

Also Known As:

ALS1 protein, human; Ipo1 protein, mouse; SOD-1 protein; SOD1 protein; SOD1 protein, human; Sod-1 protein, mouse; Sod1 protein, mouse; Sod1 protein, rat; superoxide dismutase 1, rat; superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) protein, human; superoxide dismutase 1, soluble, mouse

Networked: 402 relevant articles (9 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Superoxide Dismutase: 7977
      - superoxide dismutase 1: 402

Experts

1.	Borchelt, David R: 17 articles (12/2014 - 03/2002)
2.	Julien, Jean-Pierre: 12 articles (01/2015 - 11/2002)
3.	Takahashi, Ryosuke: 11 articles (08/2014 - 12/2002)
4.	Urushitani, Makoto: 8 articles (06/2015 - 12/2002)
5.	Sobue, Gen: 8 articles (01/2011 - 08/2002)
6.	Brown, Robert H: 7 articles (04/2014 - 05/2007)
7.	Turner, Bradley J: 7 articles (04/2014 - 10/2003)
8.	Prudencio, Mercedes: 7 articles (01/2014 - 02/2009)
9.	Shaw, Pamela J: 6 articles (06/2014 - 08/2005)
10.	Cleveland, Don W: 5 articles (12/2015 - 02/2002)

Related Diseases

1.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/01/2010 - "Vaccinations targeting extracellular superoxide dismutase 1 (SOD1) mutants are beneficial in mouse models of amyotrophic lateral sclerosis (ALS). " 01/01/2011 - "RNA interference (RNAi) is a potential cure for amyotrophic lateral sclerosis (ALS) caused by dominant, gain-of-function superoxide dismutase 1 (SOD1) mutations. " 10/01/2009 - "In this issue of Genes & Development, Hetz and colleagues (pp. 2294-2306) surprisingly show that inhibition of the UPR by knockout of XBP-1 causes a massive increase in autophagy, enhances clearance of superoxide dismutase 1 (SOD1) aggregates, and delays the development of amyotrophic lateral sclerosis. " 10/01/2015 - "Drug discovery for amyotrophic lateral sclerosis (ALS) has experienced a surge in clinical studies and remarkable preclinical milestones utilizing a variety of mutant superoxide dismutase 1 model systems. " 06/25/2015 - "In this study, we analyzed the spatiotemporal alterations of phospholipid composition in the spinal cord of an amyotrophic lateral sclerosis (ALS) mouse model (G93A-mutated human superoxide dismutase 1 transgenic mice [SOD1(G93A) mice]) using imaging mass spectrometry (IMS), a powerful method to visualize spatial distributions of various types of molecules in situ. "
2.	Muscular Atrophy (Muscle Atrophy) 03/27/2015 - "In this study we analyzed the effects of ALS on bone using the well established G93A transgenic mouse model, which harbors an ALS-causing mutation in the gene encoding superoxide dismutase 1. We found that 4-month-old G93A mice with severe muscle atrophy had dramatically reduced trabecular and cortical bone mass compared with their sex-matched wild type (WT) control littermates. " 12/01/2013 - "Muscle-restricted expression of the fALS protein mutSOD1 (mutant superoxide dismutase 1) induces muscle atrophy and motoneuron death. " 01/01/2015 - "Importantly, we also observed an induction of Notch3 and Hes1 expression in two murine models of muscle atrophy: a doxorubicin-induced cachexia model and an ALS murine model expressing mutated superoxide dismutase 1. In both models, the induction of Notch3 and Hes1 were partially opposed by AGT251, which correlated with ameliorations in body and muscle weight, reduction of muscular atrophy markers, and improved survival. "
3.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2008 - "Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study." 05/01/2014 - "Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginine/serin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy." 07/01/2015 - "Both agents did not modify these parameters but t-AUCB increased the expression of the antioxidant enzyme superoxide dismutase 1. These results demonstrate that, independently from its glucose-lowering effect, sEH inhibition prevents microalbuminuria and renal inflammation in overweight hyperglycemic mice, suggesting that this pharmacological strategy could be useful in the management of diabetic nephropathy. "
4.	Inflammation 01/01/2015 - "Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation." 01/01/2013 - "The inflammation is driven by stimulation of macrophages by aggregated superoxide dismutase 1 (SOD1) through caspase1, interleukin 1 (IL1), IL6 and chemokine signaling. " 07/01/2015 - "Both agents did not modify these parameters but t-AUCB increased the expression of the antioxidant enzyme superoxide dismutase 1. These results demonstrate that, independently from its glucose-lowering effect, sEH inhibition prevents microalbuminuria and renal inflammation in overweight hyperglycemic mice, suggesting that this pharmacological strategy could be useful in the management of diabetic nephropathy. " 12/01/2015 - "We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. " 06/01/2014 - "Insulin resistance, serum lipids, inflammation markers, hepatic lipids, lipid peroxides, and glutathione (GSH) levels together with glutathione peroxidase (GSH-Px) and superoxide dismutase 1 (CuZnSOD; SOD1) activities and their protein expressions were measured. "
5.	Weight Loss (Weight Reduction) 09/06/2013 - "We evaluated if gender affect the disease course, the motor performance, the weight loss and the lifespan in mice overexpressing mutant superoxide dismutase 1. We measured motor impairment, motor strength and coordination by rotarod and grip strength testing. " 01/01/2015 - "Importantly, we also observed an induction of Notch3 and Hes1 expression in two murine models of muscle atrophy: a doxorubicin-induced cachexia model and an ALS murine model expressing mutated superoxide dismutase 1. In both models, the induction of Notch3 and Hes1 were partially opposed by AGT251, which correlated with ameliorations in body and muscle weight, reduction of muscular atrophy markers, and improved survival. " 01/01/2012 - "Weight reduction was associated with markedly reduced plasma levels of plasminogen activator inhibitor-1, Factor VII and Factor VIII. Reduced oxidative stress and inflammation following weight reduction is supported by significantly lower expression in adipose tissues of pro-inflammatory interleukin-6, higher expression of anti-oxidant catalase, superoxide dismutase 1 and glutathione peroxidase 1, and lower plasma levels of C-reactive protein. "

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	Glucose (Dextrose)
3.	Doxorubicin (Adriamycin)
4.	4- (4- (3- adamantan- 1- ylureido)cyclohexyloxy)benzoic acid
5.	ethidium homodimer
6.	Proteins (Proteins, Gene)
7.	Copper
8.	Superoxide Dismutase
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Catalase

Related Therapies and Procedures

1.	Axotomy
2.	Transplantation (Transplant Recipients)
3.	Tissue Therapy (Cell Therapy)
4.	Lasers (Laser)
5.	Injections