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eleutherobin

structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - eleutherobin: 3

Experts

1.	Joshi, Penny: 1 article (08/2008)
2.	Rawat, Diwan S: 1 article (08/2008)
3.	Sharma, Mukul: 1 article (08/2008)
4.	Singh, Ram: 1 article (08/2008)
5.	Andreu, José M: 1 article (12/2005)
6.	Barasoain, Isabel: 1 article (12/2005)
7.	Buey, Rubén M: 1 article (12/2005)
8.	Díaz, J Fernando: 1 article (12/2005)
9.	Giannakakou, Paraskevi: 1 article (12/2005)
10.	Jackson, Evelyn: 1 article (12/2005)

Related Diseases

1.	Neoplasms (Cancer) 03/15/1998 - "Eleutherobin is a novel natural product isolated from a marine soft coral that is extremely potent for inducing tubulin polymerization in vitro and is cytotoxic for cancer cells with an IC50 similar to that of paclitaxel. " 08/01/2008 - "Didemnin was the first marine peptide that entered in human clinical trials in US for the treatment of cancer and other compounds such as dolastatin-10, soblidotin, didemnin B, ecteinascidin 743, girolline, aplidine, cryptophycins (also arenastatin A), bryostatin 1, ILX 651, kahalalide F, E7389, discodermolide, ES-285 (spisulosine), HTI-286 (hemiasterlin derivative), squalamine, KRN-7000, vitilevuamide, Laulimalide, Curacin A, diazonamide, peloruside A, eleutherobin, sarcodictyin, thiocoraline, salicylihalimides A, ascididemnin, CGX-1160, CGX-1007dictyodendrins, GTS-21 (aka DMBX), manoalide, IPL-576,092 (aka HMR-4011A) have entered in the clinical trials. "
2.	Carcinoma (Carcinomatosis) 03/15/1998 - "Human colon carcinoma cells exposed to eleutherobin contain multiple micronuclei and microtubule bundles, and they arrest in mitosis, depending on concentration, cell line, and length of exposure. " 12/01/2005 - "The binding constants of epothilones, eleutherobin, discodermolide, sarcodictyins, 3,17beta-diacetoxy-2-ethoxy-6-oxo-B-homo-estra-1,3,5(10)-triene, and dictyostatin to the paclitaxel site; the critical concentrations of ligand-induced assembly; and their cytotoxicity in carcinoma cells have been measured, and correlations between these parameters have been determined. "

Related Drugs and Biologics

1.	discodermolide
2.	Depsipeptides
3.	Peptides (Polypeptides)
4.	Trabectedin
5.	girolline
6.	tasidotin
7.	HTI-286
8.	hemiasterlin
9.	vitilevuamide
10.	peloruside A