latency-associated nuclear antigen

a major nuclear antigen of the Kaposi's sarcoma-associated herpesvirus (KSHV); the 222-234 kDa latent nuclear protein (LNA) encoded by orf73 is a component of LANA; over 85% of patients with KS are seropositive for LANA

Also Known As:

Networked: 131 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Robertson, Erle S: 18 articles (12/2021 - 06/2004)
2.	Verma, Subhash C: 12 articles (07/2021 - 06/2004)
3.	Cai, Qiliang: 9 articles (12/2021 - 08/2006)
4.	Schulz, Thomas F: 7 articles (09/2020 - 01/2002)
5.	Kaye, Kenneth M: 6 articles (12/2021 - 12/2004)
6.	Lu, Jie: 6 articles (07/2021 - 07/2009)
7.	Lan, Ke: 6 articles (05/2012 - 06/2004)
8.	Xiao, Bingyi: 4 articles (07/2021 - 07/2009)
9.	Renne, Rolf: 4 articles (07/2014 - 11/2002)
10.	Si, Huaxin: 4 articles (01/2012 - 01/2006)

Related Diseases

1.	Kaposi Sarcoma (Kaposi's Sarcoma) 04/01/2017 - "Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency." 07/01/2015 - "The histologic diagnosis of Kaposi sarcoma (KS) can be confirmed with human herpes virus 8 (HHV8) latency-associated nuclear antigen (LNA)-1 immunohistochemistry, which may show variability in distribution and intensity. " 12/01/2011 - "Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. " 04/13/2007 - "The latency-associated nuclear antigen (LANA-1) of Human Herpes Virus 8 (HHV-8), alternatively called Kaposi Sarcoma Herpes Virus (KSHV) is constitutively expressed in all HHV-8 infected cells. " 02/01/2007 - "In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus."
2.	Infections 05/01/2012 - "Previous studies have proposed a feedback model in which the viral replication and transcription activator (RTA) can induce the expression of the latency-associated nuclear antigen (LANA) during early infection. " 12/21/2021 - "25HC blocks KSHV de novo infection of primary endothelial cells at a postentry step and decreases viral gene expression of LANA (latency-associated nuclear antigen) and RTA. " 09/15/2020 - "Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections." 12/15/2017 - "KSHV establishes lifelong infections using its latency-associated nuclear antigen (LANA). " 01/01/2016 - "Utilizing a genetic screen of latent genes in the context of KSHV genome, we identified the latency-associated nuclear antigen (LANA) to be responsible for the genome-wide recruitment of PRCs onto the lytic promoters following infection. "
3.	Lymphoma (Lymphomas) 09/01/2006 - "Immunohistochemical study showed that the lymphoma cells strongly expressed CD45, CD30, and KSHV/HHV8 latency-associated nuclear antigen. " 11/25/1999 - "The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells." 03/01/2006 - "The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma." 05/01/2003 - "Additionally, three of seven evaluable cases of the immunoblastic variant of diffuse large B-cell lymphoma (immunoblastic lymphoma) showed similar latency-associated nuclear antigen staining. " 09/01/2001 - "The latency-associated nuclear antigen (LANA) is constitutively expressed in cells infected with the Kaposi's sarcoma (KS) herpesvirus (KSHV), also referred to as human herpesvirus 8. KSHV is tightly associated with body cavity-based lymphomas (BCBLs) in immunocompromised patients infected with human immunodeficiency virus (HIV). "
4.	Hypoxia (Hypoxemia) 01/01/2012 - "Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors." 06/01/2014 - "Our previous studies showed that the hypoxia-sensitive chromatin remodeler KAP1 was targeted by the KSHV-encoded latency-associated nuclear antigen (LANA) to repress expression of the major lytic replication and transcriptional activator (RTA). " 08/01/2006 - "Here we show that the latency-associated nuclear antigen (LANA), which plays a crucial role in modulating viral and cellular gene expression, directly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha). " 01/01/2012 - "In the present study, we show that hypoxia increases the levels of mRNAs encoding KSHV latency-associated nuclear antigen (LANA) in primary effusion lymphoma (PEL) cell lines and also increases the levels of LANA protein. "
5.	Neoplasms (Cancer) 01/01/2018 - "A limited repertoire of FcaGHV transcripts was identified in five tumors, including homologs of oncogenic latency-associated transcripts, latency-associated nuclear antigen (LANA, ORF73) and vFLIP (F7), lytic genes (ORF50, ORF6, ORF59, F10), and an ORF unique to FcaGHV1, F20. " 01/01/2012 - "The Kaposi sarcoma associated herpesvirus (KSHV) latency associated nuclear antigen (LANA) is expressed in all KSHV associated malignancies and is essential for maintenance of KSHV genomes in infected cells. " 09/01/2011 - "The latency-associated nuclear antigen (LANA) is central to the maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) and to the survival of KSHV-carrying tumor cells. " 01/01/2011 - "Latency-associated nuclear antigen (LANA)-1 plays an important role in the pathogenesis of KSHV-associated malignancies through inhibition of apoptosis and maintenance of latency. " 06/30/2008 - "Selected archival diagnostic biopsies (n = 184) and sera from indigenous patients with KS (n = 120), non-KS tumors (n = 24) and non-neoplastic lesions (n = 40) at Muhimbili National Hospital (MNH), Tanzania, were evaluated by diagnostic histopathology, immunohistology [anti-HHV-8 latency-associated nuclear antigen (LANA)] and serology for HIV (ELISA) and HHV-8 (IFA and ELISA). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Chromatin
3.	Ubiquitin
4.	Cytokines
5.	Interferons
6.	Survivin
7.	Paraffin
8.	Cyclins
9.	Antigens
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)