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ASIC channel

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vertebrate proton-gated sodium channel isolated from dorsal root ganglion cells; RefSeq NM_007384 (Accn1, mouse); NM_009597 (Accn2, mouse); NM_024154 (Accn2, rat); NM_020039 (ACCN2, human); NM_018674 (ACCN4, human)

Also Known As:

ACCN2 protein, human; ACCN4 protein, human; ASIC protein, human; ASIC protein, mouse; ASIC1 protein, mouse; ASIC1A protein, human; ASIC1A protein, mouse; ASIC1a protein, rat; ASIC1b protein, rat; ASIC2 protein, mouse; ASIC2a protein, mouse; ASIC3 protein, rat; ASIC4 protein, human; Accn1 protein, mouse; Accn2 protein, mouse; Accn2 protein, rat; Accn3 protein, rat; Asic1 protein, rat; BNAC2 protein, rat; BNAC4 protein, human; BNaC2 channel, human; BNaC2 protein, human; Brain sodium channel 2 protein, human; DRASIC channel, rat; DRASIC protein, rat; acid-sensing ioin channel 3, rat; acid-sensing ion channel 1, mouse; acid-sensing ion channel 1, rat; acid-sensing ion channel 2, mouse; acid-sensing ion channel 4, human; acid-sensing ion channels; amiloride-sensitive cation channel 1, neuronal (degenerin) protein, mouse; amiloride-sensitive cation channel 2, neuronal protein, human; amiloride-sensitive cation channel 2, neuronal protein, mouse; amiloride-sensitive cation channel 3, rat; amiloride-sensitive cation channel 4, pituitary protein, human; amiloride-sensitive cation channel neuronal 2 protein, rat; brain Na(+) channel 2, human; brain sodium channel 4 protein, human; hBNaC2; hydrogen-gated sodium channel DRASIC, rat; rASIC3 channel, rat

Networked: 154 relevant articles (2 outcomes, 16 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Xiong, Zhi-Gang: 11 articles (02/2014 - 09/2004)
2.	Xu, Tian-Le: 9 articles (01/2015 - 01/2007)
3.	Wemmie, John A: 8 articles (06/2014 - 12/2003)
4.	Lingueglia, Eric: 7 articles (05/2014 - 05/2002)
5.	Chu, Xiang-Ping: 7 articles (02/2014 - 09/2004)
6.	Lazdunski, Michel: 7 articles (10/2012 - 05/2002)
7.	Simon, Roger P: 7 articles (10/2010 - 09/2004)
8.	Sluka, Kathleen A: 6 articles (07/2015 - 12/2003)
9.	Qiu, Chun-Yu: 5 articles (12/2015 - 01/2012)
10.	Hu, Wang-Ping: 5 articles (12/2015 - 01/2012)

Related Diseases

1.	Pain (Aches) 06/01/2008 - "Advances in molecular and transgenic approaches have helped to identify novel therapeutic targets for the treatment of pain from tissue and nerve damage such as acid-sensing ion channels, transient receptor potential and NaV channels. " 02/01/2015 - "This study shows that l-THP can exert an inhibitory effect on the functional activity of native acid-sensing ion channels (ASICs), which are believed to mediate pain caused by extracellular acidification. " 10/10/2007 - "Previous pharmacological and behavioral studies suggest that peripheral acid-sensing ion channels (ASICs) contribute to pain sensation, and the expression of ASIC subunits is elevated in the rat spinal dorsal horn (SDH) in an inflammatory pain model. " 03/01/2015 - "Acid-sensing ion channels detect moderate acidifications to induce ocular pain." 01/01/2015 - "Acid-sensing ion channels: a novel therapeutic target for pain and anxiety."
2.	Acidosis 12/01/2015 - "Moreover, E2 can exert a rapid potentiating effect on the functional activity of acid-sensing ion channels (ASICs), which mediated the acidosis-induced events. " 02/15/2014 - "Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. " 02/01/2013 - "Although it is well known that many transporters in the retinal pigment epithelium (RPE) cells can maintain pH homeostasis efficiently, other receptors in RPE may also be involved in sensing acidosis, such as acid-sensing ion channels (ASICs). " 01/01/2013 - "Because acidosis can activate acid sensing ion channels (ASICs), we also studied ASIC1a(-/-) mice and found reduced neurodegeneration after FPI. " 01/01/2013 - "Extracellular acidosis is involved in various pathological situations of central nervous system and the effects are largely mediated by acid sensing ion channels (ASICs). "
3.	Stroke (Strokes) 01/01/2013 - "The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke intervention." 07/01/2010 - "Acid-sensing ion channels (ASICs) are cationic channels that are activated by extracellular acidification and implicated in pain perception, ischemic stroke, mechanosensation, learning, and memory. " 01/01/2006 - "Thus, targeting the Ca(2+)-permeable acid-sensing ion channels may prove to be a novel neuroprotective strategy for stroke patients." 12/01/2005 - "Acid sensing ion channels (ASIC) members of the ENaC degenerine channel family, have been shown to participate in various sensorial pathways including nociception, also they have been shown to participate in synaptic transmission, learning and memory processes and in the physiopathology of the ischemic stroke. " 04/01/2007 - "Acid-sensing ion channels (ASICs) are thought to trigger some forms of acid-induced pain and taste, and to contribute to stroke-induced neural damage. "
4.	Ischemia 04/01/2005 - "Recent studies on neuroprotection in ischemia have demonstrated that the activation of neuronal acid-sensing ion channels type 1 (ASIC-1) can lead to neuronal death. " 01/01/2013 - "We also discuss the important roles of transient receptor potential (TRP) channels and acid-sensing ion channels (ASICs) in responses to ischemia. " 07/31/2009 - "Acid-sensing ion channels (ASICs) are Na+ channels that are activated by acidic pH. Their expression in cardiac afferents and remarkable sensitivity to small pH changes has made them leading candidates to sense cardiac ischemia. " 02/01/2013 - "Acid-sensing ion channels (ASICs) are expressed in skeletal muscle afferents, in which they sense extracellular acidosis and other metabolites released during ischemia and exercise. " 10/01/2009 - "However, little is known about the role of TK in ischemia-acidosis-induced injury, which is partially caused by the activation of acid-sensing ion channels (ASICs). "
5.	Brain Ischemia (Cerebral Ischemia) 05/05/2013 - "This study sought to observe the expression characteristics of permeable Ca(2+)-acid-sensing ion channels during different reperfusion inflows in rats after cerebral ischemia. " 01/01/2015 - "Acid sensing ion channels (ASICs), activated by lowering extracellular pH, play an important role in normal synaptic transmission in brain and in the pathology of brain ischemia. " 09/29/2006 - "Acid-sensing ion channels (ASICs), activated by lowering extracellular pH (pH(o)), play an important role in normal synaptic transmission in brain and in the pathology of brain ischemia. " 02/19/2013 - "[Effect of mild hypothermia on the expression of acid-sensing ion channels 1a and 2a following global cerebral ischemia-reperfusion in rats]." 01/01/2007 - "The recent finding that acidosis activates a distinct family of cation channels, the acid-sensing ion channels (ASICs), in both peripheral and central neurons has dramatically changed the landscape of brain ischemia neurochemistry and provided a novel therapeutic target. "

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