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BAY y 5959
Also Known As:
R-isopropyl-2-amino-5-cyano-1,4-dihydro-6-methyl-4-(3-phenylquinolin-5-yl)pyridine-3-carboxylate
Networked:
5
relevant articles (
0
outcomes,
3
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Dihydropyridines: 214
BAY y 5959: 5
Related Diseases
1.
Heart Failure
08/01/1998 - "
The effects of BAY y 5959 (2-h i.v. infusions of 3 microg/kg/min and 10 microg/kg/min) were determined before heart failure, after heart failure was established and then 2 h after the end of a 5-day continuous BAY y 5959 intra-atrial infusion.
"
12/01/1997 - "
BAY y 5959 exhibits positive inotropic effects in patients with and without heart failure.
"
09/29/1998 - "
The aim of this study was to determine the mechanism by which the calcium channel promoter BAY y 5959 affects the control of heart rate and baroreflex sensitivity in conscious dogs with pacing-induced heart failure (HF).
"
08/01/1998 - "
Hemodynamic effects of a calcium channel promoter, BAY y 5959, are preserved after chronic administration in ischemic heart failure in conscious dogs.
"
01/01/1998 - "
Whereas inotropic responsiveness to isoproterenol was blunted in embolized hearts, these actions of BAY y 5959 were relatively preserved in the heart failure state.
"
2.
Body Weight (Weight, Body)
12/01/1997 - "
Hemodynamic variables (including left ventricular [LV] angiography) and plasma samples were obtained at baseline and after 20 min of intravenous infusion of BAY y 5959 at doses ranging from 0.25 to 4.5 microg/kg body weight per min. In both study groups, BAY y 5959 produced dose-dependent increases in the indexes of inotropic state, without affecting isovolumetric relaxation rate.
"
3.
Bradycardia
09/29/1998 - "
Surprisingly, the autonomically mediated bradycardia induced by BAY y 5959 was also preserved in HF.
"
08/01/1998 - "
In CHF, BAY y 5959 continued to induce dose-dependent increases in left ventricular systolic pressure, LVdP/dt and mean arterial pressure, as well as causing bradycardia and a significant decrease in left ventricular end-diastolic pressure.
"
08/01/1998 - "
Before CHF, the positive inotropic effect of BAY y 5959 at a dose of 10 microg/kg/min [left ventricular dP/dt (LVdP/dt) increased from 2955 +/- 132 mmHg to 4897 +/- 426 mmHg, P < .05] was associated with bradycardia (HR decreased from 92 +/- 4 to 78 +/- 6 b/min, P <.05), slight increases in mean arterial pressure (it increased from 100 +/- 2 mmHg to 113 +/- 5 mmHg, P <.05) and did not alter left ventricular end-diastolic pressure.
"
12/01/1997 - "
BAY y 5959 also induced mild but statistically significant bradycardia and significantly decreased end-systolic volume while producing a leftward shift of the pressure-volume loop.
"
Related Drugs and Biologics
1.
Calcium Channels (Calcium Channel)
2.
Calcium
3.
Dobutamine
4.
Isoproterenol (Isoprenaline)
Related Therapies and Procedures
1.
Intravenous Infusions