darbufelone

RN given for (Z)-isomer and monomethanesulfonate salt; structure in first source

Also Known As:

5-((3,5--bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-2-imino-4-thiazolidinone methanesulfonate; CI 1004; CI-1004; PD0136095-73; darbufelone mesylate

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidines: 105
      - darbufelone: 5

Experts

1.	Kapelka, I: 1 article (01/2021)
2.	Koiro, O: 1 article (01/2021)
3.	Kudina, O: 1 article (01/2021)
4.	Merzlikin, S: 1 article (01/2021)
5.	Shtrygol, S: 1 article (01/2021)
6.	Yudkevych, T: 1 article (01/2021)
7.	Che, Xiao-Hang: 1 article (03/2016)
8.	Chen, Chun-Lin: 1 article (03/2016)
9.	Chen, Xiaodong: 1 article (03/2016)
10.	Chen, Yi-Chen: 1 article (03/2016)

Related Diseases

1.	Lewis Lung Carcinoma 07/01/2010 - "The in vivo effect of darbufelone was assessed in Lewis lung carcinoma mice model. " 07/01/2010 - "Lewis lung carcinoma growth was also significantly inhibited by darbufelone treatment at daily dose of 80 mg/kg. Taken together, these studies suggested that darbufelone, an anti-inflammation drug, might represent a novel therapeutic approach for lung cancer treatment."
2.	Lung Neoplasms (Lung Cancer) 07/01/2010 - "The aim of our study was to investigate whether darbufelone, a novel anti-inflammatory drug, has anticancer effects in lung cancer. " 07/01/2010 - "Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo." 07/01/2010 - "Lewis lung carcinoma growth was also significantly inhibited by darbufelone treatment at daily dose of 80 mg/kg. Taken together, these studies suggested that darbufelone, an anti-inflammation drug, might represent a novel therapeutic approach for lung cancer treatment."
3.	Inflammation (Inflammations) 07/01/2010 - "Lewis lung carcinoma growth was also significantly inhibited by darbufelone treatment at daily dose of 80 mg/kg. Taken together, these studies suggested that darbufelone, an anti-inflammation drug, might represent a novel therapeutic approach for lung cancer treatment."
4.	Tuberculosis (Tuberculoses) 06/04/2009 - "Among 378,506 U.S.-bound refugees, smear-negative tuberculosis was diagnosed in 3923 and inactive tuberculosis in 10,743, representing prevalences of 1036 cases per 100,000 persons (95% CI, 1004 to 1068) and 2838 cases per 100,000 persons (95% CI, 2785 to 2891), respectively. "
5.	Hypothermia 01/01/2021 - "A tendency to reduce the severity of hypothermia was observed in the group of animals treated by etoricoxib, darbufelone mesylate, and montelukast. "

Related Drugs and Biologics

1.	Etoricoxib
2.	montelukast (Singulair)