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embusartan

Also Known As:

6-n-butyl-4-methoxycarbonyl-2-oxo-1-((2'-(1H-tetrazol-5-yl)-3-fluorobiphenyl-4-yl)methyl)-1,2-dihydropyridine; BAY 10-6734; BAY-10-6734; embu-sartan

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - embusartan: 2
  - Pyridines: 88
    - Dihydropyridines: 214
      - embusartan: 2

Experts

1.	Leenen, F H: 1 article (03/2001)
2.	Zhang, J: 1 article (03/2001)

Related Diseases

1.	Stroke (Strokes) 09/01/1997 - "These studies were designed to investigate the protective effects of the new angiotensin II receptors antagonist BAY 10-6734 (6-n-butyl-4-methoxycarbonyl-2-oxo-1[(2'-(1H-tetrazol-5-yl) -3-fluorobiphenyl-4-yl)methyl] 1,2-dihydropyridine, CAS 156001-18-2) on haemodynamic, hormonal, renal, and structural parameters in renin transgenic rats (TGR(mRen2)27), salt-loaded Dahl S and R rats, and salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SP) in long-term trials. "
2.	Cardiomegaly (Heart Hypertrophy) 09/01/1997 - "Study 1: In SHR-SP the development of blood pressure, cardiac hypertrophy, and the deleterious effects of salt loading on kidney structure and kidney function was prevented by BAY 10-6734. " 09/01/1997 - "Study 2: In salt-loaded Dahl S rats with a suppressed plasma renin activity treatment with BAY 10-6734 did not delay the increase in blood pressure but prevented cardiac hypertrophy and the increase in plasma ANP (Atrial natriuretic peptide). "
3.	Hypertension (High Blood Pressure) 09/01/1997 - "The beneficial effects of BAY 10-6734 in these different animal hypertension models are also emphasized by a reduction in mortality." 03/01/2001 - "We concluded that peripheral administration of losartan as well as embusartan can cause sufficient central effects to prevent the sympathetic hyperactivity and hypertension induced by chronic peripheral ouabain and central sodium." 03/01/2001 - "Simultaneous treatment with losartan or embusartan fully prevented hypertension, maintained normal responses to air stress and guanabenz, and attenuated pressor responses to acute intracerebroventricular injection of ANG II and ouabain. "

Related Drugs and Biologics

1.	Salts
2.	Renin
3.	Angiotensin II
4.	1,4-dihydropyridine (dihydropyridine)
5.	Atrial Natriuretic Factor (ANF)
6.	Losartan (Cozaar)
7.	Sodium
8.	Ouabain (G Strophanthin)
9.	Guanabenz (BR 750)