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S 0509

a CCK-B receptor antagonist; structure in first source

Also Known As:

2-(N-(tert-butoxycarbonylmethyl)-N-(N'-(m-carboxyphenyl)ureidomethylcarbonyl)amino)benzophenone; S-0509

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Adachi, Kyoichi: 1 article (12/2003)
2.	Ishihara, Shunji: 1 article (12/2003)
3.	Ishihara, Yasunobu: 1 article (12/2003)
4.	Kazumori, Hideaki: 1 article (12/2003)
5.	Kinoshita, Yoshikazu: 1 article (12/2003)
6.	Ono, Masahiro: 1 article (12/2003)
7.	Ortega-Cava, Cesar Francisco: 1 article (12/2003)
8.	Rumi, Mohammad Azharul Karim: 1 article (12/2003)
9.	Sato, Hiroshi: 1 article (12/2003)
10.	Yuki, Mika: 1 article (12/2003)

Related Diseases

1.	Gastric Fistula 04/01/2000 - "Similarly to the Heidenhain pouch model, even in the gastric fistula (GF) model, S-0509 significantly inhibited pentagastrin-stimulated gastric acid secretion, yet the drug had no effect on carbachol-stimulated secretion. " 05/01/1999 - "In chronic gastric fistula rats, S-0509 also significantly inhibited pentagastrin- and carbachol-stimulated gastric acid secretion in a dose-related manner, but had no effect on histamine-stimulated secretion. "
2.	Ulcer 05/01/1999 - "Antisecretory and ulcer healing effects of S-0509, a novel CCK-B/gastrin receptor antagonist, in rats." 05/01/1999 - "The effects of a novel CCK-B/gastrin receptor antagonist, S-0509, on gastric acid secretion and the healing of acetic acid ulcers in rats were examined. " 05/01/1999 - "A two-week treatment with S-0509 markedly enhanced the spontaneous healing of acetic acid ulcers and prevented the delay in ulcer healing caused by indomethacin. " 05/01/1999 - "In addition, S-0509 markedly inhibited pentagastrin- and carbachol-stimulated acid secretion in both normal rats and rats with ulcers, but failed to inhibit histamine-stimulated secretions. "
3.	Stomach Ulcer (Gastric Ulcer) 05/01/1999 - "S-0509, orally administered 1, 6, and 12 hr prior to a 3-hr pylorus ligation, significantly inhibited basal gastric acid secretion in both normal rats and rats with gastric ulcers. "
4.	Spontaneous Remission 05/01/1999 - "A two-week treatment with S-0509 markedly enhanced the spontaneous healing of acetic acid ulcers and prevented the delay in ulcer healing caused by indomethacin. "
5.	Peptic Ulcer (Peptic Ulcers) 05/01/1999 - "It is concluded that S-0509 is a promising new antisecretory drug for the treatment of peptic ulcers."

Related Drugs and Biologics

1.	Cholecystokinin B Receptor
2.	Pentagastrin (Peptavlon)
3.	Carbachol (Carbastat)
4.	Acids
5.	Acetic Acid (Vinegar)
6.	Omeprazole (Prilosec)
7.	Indomethacin (Indometacin)
8.	Histamine (Histamine Dihydrochloride)
9.	Gastrins

Related Therapies and Procedures

1.	Ligation