HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

SB 222200

Also Known As:

N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-carboxamide; SB-222200

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - SB 222200: 4

Experts

1.	Flynn, Francis W: 1 article (08/2007)
2.	Haley, Gwendolen E: 1 article (08/2007)
3.	King, Andrew G: 1 article (03/2005)
4.	Sanger, Gareth J: 1 article (03/2005)

Related Diseases

1.	Miosis 10/01/1997 - "[MePhe7]-NKB-induced miosis was inhibited by SB 222200 (5mg kg-1, i.v., i.e. " 10/01/1997 - "Senktide-induced miosis was inhibited by SB 222200 (1 and 2 mg kg[-1], i.v., i.e. " 10/01/1997 - "In addition, NK3 receptor agonist-induced miosis in conscious rabbits is a good in vivo correlate of the in vitro rabbit iris sphincter muscle preparation and appears to be a useful model for characterizing the pharmacodynamic profile and efficacy of structurally distinct NK3 receptor antagonists, such as SB 222200, SB 223412, SB 218795 and SR 142801."
2.	Vomiting 03/07/2005 - "Given the reported location of NK-3 receptors within the rat brainstem vagal motor and sensory nuclei, we investigated the ability of SB-222200, a brain-penetrant NK-3 receptor antagonist, to interfere with emesis evoked in ferrets by the emetogenic cytotoxic agent cisplatin. " 03/07/2005 - "In contrast to control anti-emetic experiments using the 5-HT3 receptor antagonist ondansetron, SB-222200 was found to have no effects on cisplatin-induced vomiting or on the associated reductions in feeding and drinking behaviors at any dose tested. "
3.	Peritonitis 07/27/2023 - "Importantly, treatment with SB-222200 demonstrates alleviation of NLRP3-dependent inflammatory diseases in mouse models, such as monosodium urate crystal-induced peritonitis and dextran sulfate sodium-induced acute intestinal inflammation. "
4.	Inflammation (Inflammations) 07/27/2023 - "Importantly, treatment with SB-222200 demonstrates alleviation of NLRP3-dependent inflammatory diseases in mouse models, such as monosodium urate crystal-induced peritonitis and dextran sulfate sodium-induced acute intestinal inflammation. "
5.	Hypotension (Low Blood Pressure) 08/01/2007 - "The contribution of NK3R activation to the release of VP and OT in response to hyperosmolarity and hypotension was evaluated by measuring the release of both hormones following pretreatment with a selective NK3R antagonist, SB-222200. " 08/01/2007 - "Freely behaving male rats were given an intraventricular injection of either 0.15 M NaCl or 250, 500, or 1,000 pmol SB-222200, and then were administered an intravenous infusion of 2 M NaCl or 0.15 M NaCl (experiment 1), or a bolus intra injection of 0.15 M NaCl or hydralazine (HDZ), a hypotension-inducing drug (experiment 2). "

Related Drugs and Biologics

1.	SB 223412
2.	SB 218795
3.	SR 142801 (osanetant)
4.	5-HT3 Serotonin Receptors (5 HT3 Receptor)
5.	Neurokinin-3 Receptors
6.	Ondansetron (Zofran)
7.	Dextran Sulfate
8.	Uric Acid (Urate)
9.	Hydralazine (Apresoline)
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Intraventricular Injections
2.	Intravenous Infusions