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SB 222200
Also Known As:
N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-carboxamide; SB-222200
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
SB 222200: 4
Experts
1.
Flynn, Francis W
: 1 article (08/2007)
2.
Haley, Gwendolen E
: 1 article (08/2007)
3.
King, Andrew G
: 1 article (03/2005)
4.
Sanger, Gareth J
: 1 article (03/2005)
Related Diseases
1.
Miosis
10/01/1997 - "
[MePhe7]-NKB-induced miosis was inhibited by SB 222200 (5mg kg-1, i.v., i.e.
"
10/01/1997 - "
Senktide-induced miosis was inhibited by SB 222200 (1 and 2 mg kg[-1], i.v., i.e.
"
10/01/1997 - "
In addition, NK3 receptor agonist-induced miosis in conscious rabbits is a good in vivo correlate of the in vitro rabbit iris sphincter muscle preparation and appears to be a useful model for characterizing the pharmacodynamic profile and efficacy of structurally distinct NK3 receptor antagonists, such as SB 222200, SB 223412, SB 218795 and SR 142801.
"
2.
Vomiting
03/07/2005 - "
Given the reported location of NK-3 receptors within the rat brainstem vagal motor and sensory nuclei, we investigated the ability of SB-222200, a brain-penetrant NK-3 receptor antagonist, to interfere with emesis evoked in ferrets by the emetogenic cytotoxic agent cisplatin.
"
03/07/2005 - "
In contrast to control anti-emetic experiments using the 5-HT3 receptor antagonist ondansetron, SB-222200 was found to have no effects on cisplatin-induced vomiting or on the associated reductions in feeding and drinking behaviors at any dose tested.
"
3.
Peritonitis
07/27/2023 - "
Importantly, treatment with SB-222200 demonstrates alleviation of NLRP3-dependent inflammatory diseases in mouse models, such as monosodium urate crystal-induced peritonitis and dextran sulfate sodium-induced acute intestinal inflammation.
"
4.
Inflammation (Inflammations)
07/27/2023 - "
Importantly, treatment with SB-222200 demonstrates alleviation of NLRP3-dependent inflammatory diseases in mouse models, such as monosodium urate crystal-induced peritonitis and dextran sulfate sodium-induced acute intestinal inflammation.
"
5.
Hypotension (Low Blood Pressure)
08/01/2007 - "
The contribution of NK3R activation to the release of VP and OT in response to hyperosmolarity and hypotension was evaluated by measuring the release of both hormones following pretreatment with a selective NK3R antagonist, SB-222200.
"
08/01/2007 - "
Freely behaving male rats were given an intraventricular injection of either 0.15 M NaCl or 250, 500, or 1,000 pmol SB-222200, and then were administered an intravenous infusion of 2 M NaCl or 0.15 M NaCl (experiment 1), or a bolus intra injection of 0.15 M NaCl or hydralazine (HDZ), a hypotension-inducing drug (experiment 2).
"
Related Drugs and Biologics
1.
SB 223412
2.
SB 218795
3.
SR 142801 (osanetant)
4.
5-HT3 Serotonin Receptors (5 HT3 Receptor)
5.
Neurokinin-3 Receptors
6.
Ondansetron (Zofran)
7.
Dextran Sulfate
8.
Uric Acid (Urate)
9.
Hydralazine (Apresoline)
10.
Hormones (Hormone)
Related Therapies and Procedures
1.
Intraventricular Injections
2.
Intravenous Infusions