platycodin D

01/01/2022 - "Platycodin D may be beneficial for the prevention or treatment of tumor angiogenesis and angiogenesis-related human diseases."
01/01/2022 - "Furthermore, immunohistochemical staining studies showed that tumors from the mice treated with platycodin D activated JNK by translocation of JNK into nuclei, increased phosphorylation of JNK and c-Jun at Ser63 in nuclei, and boosted the PUMA expression. "
01/01/2022 - "Previous studies report that Platycodin D (PD) exhibits anti-tumor effects in multiple human cancers, including NSCLC, but the underlying mechanisms are largely unknown. "
01/01/2022 - "Studies have shown that platycodin D has several pharmacological effects like anti-inflammatory, immunomodulatory, and anti-tumor effects, while the effect and mechanism of platycodin D on PTC are still unclear. "
09/01/2017 - "In vivo studies confirmed that platycodin D retarded the growth of subcutaneous SCC-4 xenograft tumors and reduced phosphorylation of NF-κB p65. "

07/01/2015 - "Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro."
01/01/2016 - "Protective Effects of Platycodin D on Lipopolysaccharide-Induced Acute Lung Injury by Activating LXRα-ABCA1 Signaling Pathway."
01/01/2016 - "The purpose of this study was to investigate the protective effects of platycodin D (PLD) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and clarify the possible mechanism. "
07/01/2021 - "Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats."

01/01/2019 - "Previous studies have suggested that platycodin D is implicated in bone biology and ameliorates osteoporosis development. "
01/01/2019 - "Taken together, these results suggested that platycodin D could be an effective therapeutic compound against osteoporosis because of its regulatory effects during the osteoblast differentiation."
01/01/2017 - "Platycodin D can be regarded as an antiosteoporotic candidate for treatment of osteoporosis diseases. "

12/02/2022 - "Studies have suggested that platycodin D (PD), one of the main active ingredients in Platycodon grandiflorum, has high bioavailability and significantly mitigates the progress of NAFLD, but the underlying mechanism of this is still unclear. "
12/02/2022 - "Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model."

11/05/2023 - "Platycodin D inhibits glioblastoma cell proliferation, migration, and invasion by regulating DEPDC1B-mediated epithelial-to-mesenchymal transition."
06/05/2023 - "Platycodin D suppresses proliferation, migration, and invasion of human glioblastoma cells through regulation of Skp2."
01/01/2022 - "Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation."
06/05/2023 - "Platycodin D (PD) is a major bioactive component of Platycodon grandiflorum, a medicinal herb that is widely used in China, and is effective against various human cancers, including glioblastoma multiforme (GBM). "
01/01/2022 - "Here, we screened 30 traditional herbal medicines to identify novel autophagy regulators and found that Platycodon grandiflorus (PG) and platycodin D (PD), a triterpenoid saponin from PG, inhibited autophagy in glioblastoma multiforme (GBM) cells. "