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V 10367

a neuroimmunophilin ligand; structure given in first source

Also Known As:

V-10,367

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - V 10367: 3

Experts

1.	Detloff, Megan R: 1 article (10/2002)
2.	Dutta, Satavisha: 1 article (10/2002)
3.	Hall, Edward D: 1 article (10/2002)
4.	Kupina, Nancy C: 1 article (10/2002)
5.	Becker, D B: 1 article (11/2000)
6.	Doolabh, V B: 1 article (11/2000)
7.	Hunter, D A: 1 article (11/2000)
8.	Jensen, J N: 1 article (11/2000)
9.	Mackinnon, S E: 1 article (11/2000)
10.	Myckatyn, T M: 1 article (11/2000)

Related Diseases

1.	Neuroblastoma 10/01/1997 - "In the present study, we show that the potent FKBP-12 inhibitor V-10,367, which lacks the structural components of FK506 required for calcineurin inhibition, increases neurite outgrowth in SH-SY5Y neuroblastoma cells and speeds nerve regeneration in the rat sciatic nerve crush model. "
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 10/01/2002 - "The authors present two studies that investigate the biochemical and histologic effects of the nonimmunosuppressive neuroimmunophilin (NIMM) ligand V-10,367 in a mouse model of traumatic brain injury (TBI). " 10/01/2002 - "Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury."
3.	Crush Injuries 11/01/2000 - "In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection injury. "

Related Drugs and Biologics

1.	Tacrolimus Binding Protein 1A (FKBP12)
2.	Calcineurin
3.	Tacrolimus (Prograf)
4.	Ligands