voltage-dependent calcium channel (P-Q type)

RefSeq NM_001252059 (isoform 2, mouse)

Also Known As:

Ca(v)2.1; Cacl1a4 protein, mouse; Cacna1a protein, mouse; Cav2.1; P-Q type VDCC; calcium channel alpha1A, mouse; calcium channel, voltage-dependent, P-Q type, alpha 1A subunit, mouse; omega-agatoxin-IVA-sensitive VDCC; sca6 protein, mouse; tottering protein, mouse

Networked: 163 relevant articles (3 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Calcium Channels: 3471
        N-Type Calcium Channels: 192
        voltage-dependent calcium channel (P-Q type): 163
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Calcium Channels: 3471
        N-Type Calcium Channels: 192
        voltage-dependent calcium channel (P-Q type): 163
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Calcium Channels: 3471
        N-Type Calcium Channels: 192
        voltage-dependent calcium channel (P-Q type): 163

Experts

1.	van den Maagdenberg, Arn M J M: 37 articles (01/2022 - 03/2004)
2.	Ferrari, Michel D: 24 articles (01/2022 - 03/2004)
3.	Pietrobon, Daniela: 13 articles (01/2015 - 10/2002)
4.	Nistri, Andrea: 10 articles (01/2021 - 08/2010)
5.	Frants, Rune R: 9 articles (03/2014 - 03/2004)
6.	Broos, Ludo A M: 8 articles (01/2017 - 03/2004)
7.	Uchitel, Osvaldo D: 8 articles (01/2015 - 09/2008)
8.	Di Guilmi, Mariano N: 7 articles (01/2015 - 07/2010)
9.	Tottene, Angelita: 7 articles (01/2015 - 10/2002)
10.	Todorov, Boyan: 6 articles (01/2022 - 12/2006)

Related Diseases

1.	Migraine with Aura (Familial Hemiplegic Migraine) 05/01/2015 - "This study investigated plasma metabolic changes in transgenic mice that harbor a gene mutation in voltage-gated CaV2.1 Ca(2+) channels previously identified in patients with familial hemiplegic migraine, a subtype of migraine with auras. " 03/01/2009 - "In the present study, we systematically compare the biophysical effects of three type-1 familial hemiplegic migraine (FHM-1) mutations in two predominant splice variants of the neuronal Ca(V)2.1 P/Q-type channel. " 10/01/2002 - "Insights into the pathogenesis of migraine with aura may be gained from a study of human Ca(V)2.1 channels containing mutations linked to familial hemiplegic migraine (FHM). " 01/01/2021 - "Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated Ca V 2.1 Ca2+ channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. " 12/01/2019 - "Gain-of-function missense mutations in the α1A subunit of neuronal CaV2.1 channels, which define Familial Hemiplegic Migraine Type 1 (FHM1), result in enhanced cortical glutamatergic transmission and a higher susceptibility to cortical spreading depolarization. "
2.	Migraine Disorders (Migraine) 01/01/2021 - "Overexpressed Na V 1.7 Channels Confer Hyperexcitability to in vitro Trigeminal Sensory Neurons of Ca V 2.1 Mutant Hemiplegic Migraine Mice." 09/01/2014 - "Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice." 03/01/2014 - "Transgenic knock-in (KI) migraine mouse models were generated that carried either the FHM1 R192Q or the S218L mutation and were shown to exhibit increased CaV2.1 channel activity. " 11/22/2013 - "The E1015K variant in the synprint region of the CaV2.1 channel alters channel function and is associated with different migraine phenotypes." 07/01/2013 - "Then, the review describes and discusses i) the functional consequences of FHM1 mutations on the biophysical properties of recombinant human Ca(V)2.1 channels and native Ca(V)2.1 channels in neurons of knockin mouse models carrying the mild R192Q or severe S218L mutations in the orthologous gene, and ii) the functional consequences of these mutations on neurophysiological processes in the cerebral cortex and trigeminovascular system thought to be involved in the pathophysiology of migraine, and the insights into migraine mechanisms obtained from the functional analysis of these processes in FHM1 knockin mice. "
3.	Neurodevelopmental Disorders 01/01/2019 - "Thus, our data raise the possibility that therapeutic agents that increase channel open probability or prolong action potential duration may be effective in combatting this and other severe neurodevelopmental disorders caused by loss-of-function mutations in CaV2.1." 01/11/2023 - "Functional Characterization of Four Known Cav2.1 Variants Associated with Neurodevelopmental Disorders." 01/01/2022 - "Complex effects on CaV2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder." 01/01/2019 - "A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating." 01/01/2015 - "Our observations support a causative role of gain-of-function CaV2.1 mutations in congenital ataxia, a neurodevelopmental disorder at the severe-most end of CACNA1A-associated phenotypic spectrum. "
4.	Brain Injuries (Brain Injury) 01/28/2016 - "These findings demonstrate that the mutant Cav2.1 channel exerts a protective effect against cryogenic brain injury in rolling Nagoya mice. " 01/28/2016 - "To examine the relationship between Cav2.1 channel function and brain injury, we induced cryogenic brain damage in homozygous rolling Nagoya (rol/rol), control wild-type (+/+), ω-agatoxin IVA-pretreated +/+ (ω-aga +/+), and ω-agatoxin IVA-post-treated +/+ (ω-aga-post-treated +/+) mice. " 01/28/2016 - "Analysis of the protective effects of a neuronal Cav2.1 calcium channel in brain injury."
5.	Channelopathies 01/01/2019 - "Zebrafish as a Model System for the Study of Severe CaV2.1 (α1A) Channelopathies." 07/01/2010 - "Studies in mice revealed that LTCCs indirectly also contribute to neurological symptoms in Ca2+ channelopathies affecting non-LTCCs, such as Cav2.1 alpha1 in tottering mice. " 10/01/2004 - "However, studies in mice revealed that LTCC dysfunction also contributes to neurological symptoms in Ca2+ channelopathies affecting non-LTCCs, such as Ca(v)2.1 alpha1 in tottering mice. " 01/01/2022 - "However, a cluster of severe CaV2.1 channelopathies have overlapping presentations which suggests that channel dysfunction in these disorders cannot always be defined bimodally as GOF or LOF. " 07/01/2010 - "For each channelopathy, the review describes the disease phenotype as well as the functional consequences of the disease-causing mutations on recombinant human CaV2.1 channels and, in the case of FHM1 and SCA6, on neuronal CaV2.1 channels expressed at the endogenous physiological level in knockin mouse models. "

Related Drugs and Biologics

1.	Calcium Channels (Calcium Channel)
2.	Q-Type Calcium Channels (Q-Type Calcium Channel)
3.	Calcium
4.	polyglutamine
5.	Neurotransmitter Agents (Neurotransmitter)
6.	Proteins (Proteins, Gene)
7.	Pregabalin (Lyrica)
8.	Prostaglandins B
9.	Adenosine Triphosphatases (ATPase)
10.	GTP-Binding Proteins (G-Protein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Feeding Methods
3.	Activities of Daily Living (ADL)