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bimoclomol

RN given for (+-)-isomer; induces stress proteins; has cytoprotective effects

Also Known As:

bimoclomol, maleate (1:1)

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jednákovits, A: 2 articles (01/2001 - 05/2000)
2.	Nánási, P P: 2 articles (01/2001 - 05/2000)
3.	McCarty, Mark F: 1 article (01/2006)
4.	Burke, Sandra E: 1 article (01/2002)
5.	Cox, Bryan F: 1 article (01/2002)
6.	Daniell, Katina M: 1 article (01/2002)
7.	Diaz, Gilbert J: 1 article (01/2002)
8.	Lubbers, Nathan L: 1 article (01/2002)
9.	Polakowski, James S: 1 article (01/2002)
10.	Wegner, Craig D: 1 article (01/2002)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/1997 - "Bimoclomol significantly reduced nerve conduction slowing and retarded the typical elevated ischaemic resistance due to streptozotocin-induced neuropathy, suggesting that the drug might be a useful treatment for diabetic peripheral neuropathies." 01/01/1997 - "Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats." 01/01/1997 - "The effect of Bimoclomol (BRLP-42), a drug under clinical development for the treatment of diabetic complications, on experimental peripheral neuropathy was examined in rats made diabetic by injection of streptozotocin. "
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/01/1998 - "Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats." 01/01/1998 - "In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances. "
3.	Brain Edema (Cerebral Edema) 01/01/1998 - "In the case of AA-induced brain edema, bimoclomol showed less pronounced (19.6%, p < 0.05) inhibitory action, and GYKI-52466 seemed to be more effective (34.2%, p < 0.05). " 01/01/1998 - "In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances. "
4.	Diabetes Complications 01/01/2001 - "Currently, bimoclomol reached the end of the Phase II clinical trial in a group of 410 patients with diabetic complications. " 01/01/1998 - "Bimoclomol (BRLP-42) is a novel antiischemic compound acting against peripheral vascular complications of diabetes mellitus (neuropathy, retinopathy, and nephropathy). " 01/01/1997 - "The effect of Bimoclomol (BRLP-42), a drug under clinical development for the treatment of diabetic complications, on experimental peripheral neuropathy was examined in rats made diabetic by injection of streptozotocin. "
5.	Ischemia 01/18/2002 - "Rats were pretreated with bimoclomol at 3, 6 or 18 h or with 42 degrees thermal stress 24 h before ischemia. " 01/18/2002 - "Thus, bimoclomol can increase HSP70 and reduce infarct size in a rat model of ischemia and reperfusion." 01/18/2002 - "Here, we addressed whether oral pretreatment of rats with bimoclomol could elevate myocardial HSP70 and reduce infarct size in a rat model of ischemia and reperfusion. " 12/01/1998 - "Bimoclomol inhibited ischemia-induced [3H]norepinephrine release from rat hippocampal slices. "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Arachidonic Acid (Vitamin F)
3.	Heat-Shock Proteins (Heat-Shock Protein)
4.	Therapeutic Uses
5.	Heavy Metals
6.	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)
7.	Zinc
8.	Tin
9.	Salicylates
10.	Prostaglandins

Related Therapies and Procedures

1.	Oral Administration