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KT 7595

inhibits farnesyl protein transferase; structure given in first source

Also Known As:

KT-7595; KT7595

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Gliotoxin: 171
        KT 7595: 1
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Gliotoxin: 171
      - KT 7595: 1

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/1997 - "We have tested the effect of the FPTase inhibitors manumycin, an analogue of farnesyl diphosphate, and KT7595, a gliotoxin derivative, on Ras farnesylation, DNA synthesis and the anchorage-dependent and -independent growth of human colon carcinoma (LoVo), hepatoma (Mahlavu and PLC/PRF/5) and gastric carcinoma (KATO III). "
2.	Carcinoma (Carcinomatosis) 01/01/1997 - "We have tested the effect of the FPTase inhibitors manumycin, an analogue of farnesyl diphosphate, and KT7595, a gliotoxin derivative, on Ras farnesylation, DNA synthesis and the anchorage-dependent and -independent growth of human colon carcinoma (LoVo), hepatoma (Mahlavu and PLC/PRF/5) and gastric carcinoma (KATO III). "

Related Drugs and Biologics

1.	Gliotoxin
2.	DNA (Deoxyribonucleic Acid)
3.	manumycin
4.	farnesyl pyrophosphate (farnesyl diphosphate)