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aspartyl-glutamyl-valyl-aspartal

a caspase inihibitor

Also Known As:

Asp-Glu-Val-Asp-al; DEVD-CHO

Networked: 18 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - aspartyl-glutamyl-valyl-aspartal: 18

Experts

1.	Sun, Ming: 1 article (01/2008)
2.	Xu, Chao: 1 article (01/2008)
3.	Zhao, Yumei: 1 article (01/2008)
4.	Callahan, Leigh A: 1 article (06/2006)
5.	Supinski, Gerald S: 1 article (06/2006)
6.	Depre, Christophe: 1 article (06/2005)
7.	Hase, Makoto: 1 article (06/2005)
8.	Sadoshima, Junichi: 1 article (06/2005)
9.	Vatner, Stephen F: 1 article (06/2005)
10.	Armstrong, Jeffrey S: 1 article (11/2004)

Related Diseases

1.	Hepatitis 04/01/1998 - "We propose here that the CPP32 subfamily plays the dominant role in Fas-mediated hepatitis, and DEVD-CHO would be an effective cure for hepatitis."
2.	Ganglion Cysts (Ganglion) 06/15/2001 - "Furthermore, DEVD-CHO, a tetrapeptide inhibitor for caspase-3 family members, reduced dramatically the fractin staining and significantly alleviated glutamate-induced cell death and DNA fragmentation in the ganglion cell layer and inner nuclear layer. " 04/06/1999 - "DEVD-CHO (Ac-Asp-Glu-Val-aspartic acid aldehyde) and DEVD-FMK (Z-Asp-Glu-Val-Asp-FMK), caspase inhibitors, when administered intraocularly at the time of optic nerve cut, at days 3 and 7 protect about 30-35% the ganglion cells from death. "
3.	Neoplasms (Cancer) 06/01/1998 - "The data indicate that alterations in expression of CD3-zeta and CD3-epsilon chains in T cells coincubated with OvCA are related to tumor-induced apoptosis, as the addition of pan-caspase inhibitors, DEVD-cho or YVAD-cho, prevents both the in vitro induction of T cell death by OvCA cells and the changes in the level of expression of CD3-zeta and CD3-epsilon chains. " 01/01/2000 - "Anti-apoptotic proteins Bcl-2, Bcl-XL and CrmA as well as peptide-inhibitors of caspases, DEVD-CHO and zVAD-FMK, failed to rescue tumor cells from Ad.asHsp70-induced cell death. "
4.	Necrosis 06/01/2004 - "Moderating the severity of the insult by decreasing OGD exposure to 60 min did not reduce the amount of necrosis, but did induce a small degree of apoptosis (a slight reduction in cell death was observed in the presence of 10 uM DEVD-CHO). " 11/01/2004 - "Cell death was not prevented with either the broad-spectrum caspase inhibitor zVADfmk or the caspase 3-specific inhibitor DEVD-CHO, indicating that cytochrome bc1-mediated ROS production results in the MPT and necrosis. "
5.	Ischemia 09/03/2003 - "Cultures treated with DEVD-CHO after preconditioning showed reduced PARP-1 cleavage and reduced resistance to subsequent ischemia. " 04/01/2003 - "Pre-perfusion with DEVD-CHO, an inhibitor of caspase-3-like proteases, completely prevented ischemia-induced DNA strand breaks, but only partially blocked cytochrome c release and mitochondrial respiratory inhibition. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Caspases
3.	Caspase Inhibitors
4.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
5.	Peptides (Polypeptides)
6.	Peptide Hydrolases (Proteases)
7.	DNA (Deoxyribonucleic Acid)
8.	tyrosyl-valyl-alanyl-aspartal
9.	aspartyl-glutamyl-valyl-aspartal
10.	Apoptosis Regulatory Proteins