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robalzotan

structure given in first source

Also Known As:

3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen tartrate monohydrate; NAD 299; NAD-299

Networked: 5 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - robalzotan: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - robalzotan: 5

Experts

1.	Afshar, Simin: 2 articles (01/2019 - 10/2018)
2.	Komaki, Alireza: 2 articles (01/2019 - 10/2018)
3.	Rohani, Ali Haeri: 2 articles (01/2019 - 10/2018)
4.	Shahidi, Siamak: 2 articles (01/2019 - 10/2018)
5.	Soleimani Asl, Sara: 1 article (01/2019)
6.	Asl, Sara Soleimani: 1 article (10/2018)
7.	Brusberg, M: 1 article (06/2009)
8.	Hjorth, S: 1 article (06/2009)
9.	Larsson, H: 1 article (06/2009)
10.	Lindström, E: 1 article (06/2009)

Related Diseases

1.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 10/01/2008 - "To investigate the efficacy and safety of the 5-hydroxytrypamine 1A (5-HT(1A)) receptor antagonist AZD7371 tartrate monohydrate (robalzotan tartrate monohydrate), termed AZD7371 here, in patients with irritable bowel syndrome (IBS). " 10/01/2008 - "Randomized, double-blind, placebo-controlled trial of the 5-HT1A receptor antagonist AZD7371 tartrate monohydrate (robalzotan tartrate monohydrate) in patients with irritable bowel syndrome."
2.	Necrosis 10/01/2018 - "In the present study, the effects of NAD-299 (5-HT1AR antagonist) and TCB-2 (5-HT2AR agonist) on learning and memory processes, hippocampal brain-derived neurotrophic factor (BDNF) levels, neuronal necrosis, and Aβ plaque production have been investigated on the intracerebroventricular (icv) injection of streptozotocin (STZ)-induced memory deficits in rats. "
3.	Memory Disorders (Memory Loss) 10/01/2018 - "In the present study, the effects of NAD-299 (5-HT1AR antagonist) and TCB-2 (5-HT2AR agonist) on learning and memory processes, hippocampal brain-derived neurotrophic factor (BDNF) levels, neuronal necrosis, and Aβ plaque production have been investigated on the intracerebroventricular (icv) injection of streptozotocin (STZ)-induced memory deficits in rats. " 10/01/2018 - "The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels and amyloid plaques in Streptozotocin-induced memory deficits in male rats."
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2019 - "This study aimed at investigating the protective effect of NAD-299 (the selective 5-HT1A receptor antagonist) and TCB-2 (the potent5-HT2A receptor agonist) on the hippocampal oxidative stress biomarkers and the number of intact neurons in streptozotocin (STZ)-induced Alzheimer's disease in rats. "
5.	AIDS-Related Complex (ARC) 06/01/2003 - "The present study tested the effect of different selective 5-HT(1A) receptor antagonists (WAY 100635, NAD-299, p-MPPI and LY 426965) in combination with a SSRI (paroxetine), on postsynaptic 5-HT function measured by increased expression of the immediate early gene, Arc. "

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Streptozocin (Streptozotocin)
3.	Serotonin (5 Hydroxytryptamine)
4.	tartaric acid (tartrate)
5.	Brain-Derived Neurotrophic Factor (BDNF)
6.	Paroxetine (Paxil)
7.	Biomarkers (Surrogate Marker)
8.	LY 426965
9.	N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamide
10.	4- (2'- methoxyphenyl)- 1- (2'- (N- (2''- pyridinyl)- 4- iodobenzamido)ethyl)piperazine