HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

dendrotoxin I

from Dendroaspis polylepis (black mamba); amino acid sequence given in first source

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Snake Venoms: 1139
    - Elapid Venoms: 169
      - dendrotoxin I: 6
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Snake Venoms: 1139
      - Elapid Venoms: 169
        dendrotoxin I: 6

Experts

1.	Sciamanna, Giuseppe: 1 article (12/2011)
2.	Wilson, Charles J: 1 article (12/2011)
3.	Beeton, C: 1 article (05/2004)
4.	Béraud, E: 1 article (05/2004)
5.	Crest, M: 1 article (05/2004)
6.	Devaux, J: 1 article (05/2004)

Related Diseases

1.	Seizures (Absence Seizure) 07/11/1997 - "Both the Mast Cell Degranulating (MCD) peptide and Dendrotoxin I (DTX(I)), two blockers of fast activation and slowly inactivating K+ channels, induced epileptiform seizures and brain damage after intracerebroventricular injection (200 pmol) in Sprague-Dawley rats. " 08/21/1989 - "Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. " 02/07/1991 - "Using electroencephalographic (EEG) recordings in freely moving rats and extracellular neuronal firing-rate recordings in hippocampal slices, we examined the effects of riluzole (RP 54274), a compound with anti-glutamate properties, against the convulsive seizures and the cellular hyperexcitability produced by the mast-cell degranulating peptide (MCD), dendrotoxin I (DTXi) and 4-aminopyridine (4-AP). "
2.	Stuttering (Stammering) 12/01/2011 - "Blockade of Kv1 channels with dendrotoxin-I (100 nM) completely abolished the stuttering firing pattern, greatly lowered the minimum firing rate, abolished gamma-band subthreshold oscillations, and slowed spike frequency adaptation. "
3.	Glioma (Gliomas) 06/23/1998 - "Dendrotoxin-I, a relatively specific blocker of Kv1.1, blocks 96% of the sustained K+ current in glioma cells, causing a shift in the resting membrane potential from -40 mV to -7 mV. These data suggest that expression of Kv1.1 contributes to setting the resting membrane potential in undifferentiated glioma cells. "
4.	Demyelinating Diseases (Demyelinating Disease) 05/01/2004 - "Their blockade by dendrotoxin-I or kaliotoxin favoured a slow delayed conduction suggesting that those Kv channel blockers exert a neurological benefit during demyelinating diseases. "

Related Drugs and Biologics

1.	mast cell degranulating peptide
2.	4-Aminopyridine (4 Aminopyridine)
3.	Riluzole
4.	Glutamic Acid (Glutamate)
5.	kaliotoxin