SB 22489G

selective for h5-HT(1B) receptors

Also Known As:

1'-methyl-5-(2'-methyl-4'-((5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)carbonyl)-2,3,6,7-tetrahydrospiro(furo(2,3-f)indole-3,4'-piperidone) hemioxalate; SB 224289; SB-224289; SB-22489G; SB224289

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Piperidones: 37
      - SB 22489G: 5
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - SB 22489G: 5
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - SB 22489G: 5

Experts

1.	Bracha, S: 1 article (06/2016)
2.	Chappell, P E: 1 article (06/2016)
3.	Goodall, C P: 1 article (06/2016)
4.	Marley, K: 1 article (06/2016)
5.	Stang, B: 1 article (06/2016)
6.	Viall, A K: 1 article (06/2016)
7.	Argüelles, Carlos F: 1 article (06/2013)
8.	Godínez-Chaparro, Beatriz: 1 article (06/2013)
9.	Granados-Soto, Vinicio: 1 article (06/2013)
10.	López-Santillán, Francisco J: 1 article (06/2013)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 05/01/1999 - "The highest dose of SB224289 did not attenuate the hypertension, tachycardia or increases in carotid blood flow induced by bolus injections of noradrenaline (0.1-3 microg kg(-1), i.v.). "
2.	Osteosarcoma (Osteogenic Sarcoma) 06/01/2016 - "Rather incubation with the specific receptor antagonist SB224289 caused reduction in osteoblast viability, with this effect more substantial in osteosarcoma cells. "
3.	Migraine Disorders (Migraine) 03/01/2002 - "The importance of 5-HT(1B) and 5-HT(1D) receptors in the actions of the anti-migraine drug naratriptan was investigated using the relatively selective 5-HT(1) receptor ligands SB224289 and BRL15572. "
4.	Hypertension (High Blood Pressure) 05/01/1999 - "The highest dose of SB224289 did not attenuate the hypertension, tachycardia or increases in carotid blood flow induced by bolus injections of noradrenaline (0.1-3 microg kg(-1), i.v.). "
5.	Hyperalgesia 06/13/2013 - "Given alone, SB 224289 or BRL 15572 did not modify per se the long-lasting secondary allodynia and hyperalgesia. "

Related Drugs and Biologics

1.	Serotonin Receptors
2.	Norepinephrine (Noradrenaline)
3.	Metoclopramide (Reglan)
4.	Ligands
5.	Ketanserin
6.	BRL 15572
7.	8- (5- (5- amino- 2,4- dimethoxyphenyl)- 5- oxopentyl)- 1,3,8- triazaspiro(4.5)decane- 2,4- dione
8.	naratriptan
9.	cyanopindolol

Related Therapies and Procedures

1.	Injections