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SKF 99101H
RN given for (E)-2-butenedioate(2:1) salt; 5-HT(1B/D) receptor agonist
Also Known As:
3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate; SKF 99101; SKF-99101H
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
SKF 99101H: 2
Related Diseases
1.
Myoclonus (Nocturnal Myoclonus)
12/29/1995 - "
Cotreatment of guinea pigs with 8-OH-DPAT (3 mg/kg s.c.) and SKF 99101H (30 mg/kg i.p.), which were inactive when given alone, gave a marked myoclonic jerk response.
"
12/29/1995 - "
The brain penetrant 5-HT1D receptor agonist 3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate (SKF 99101H) (3-30 mg/kg i.p.) and the selective 5-HT1A receptor agonist (+/-)8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (0.3-3 mg/kg s.c.) dose dependently potentiated the frequency and intensity of myoclonic jerks caused by 5-HTP (100 mg/kg).
"
2.
Hypothermia
07/01/1998 - "
Marmosets were treated with saline or the brain penetrant, 5-HT1A/B/D receptor agonist SKF-99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (0.3-3 mg/kg SC), which has previously been shown to induce hypothermia in guinea pigs.
"
Related Drugs and Biologics
1.
SKF 99101H
2.
5-HT1D Serotonin Receptor
3.
5-HT1A Serotonin Receptor
4.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
5.
5-Hydroxytryptophan (5 Hydroxytryptophan)
6.
tetralin