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NE 10244

inhibits tumor cell adhesion to extracellular matrices; structure in first source

Also Known As:

2-(N-methyl-3-pyridinyl)-1-hydroxyethylidene bisphosphonic acid; NE-10244

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - Diphosphonates: 11565
      - NE 10244: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridinium Compounds: 5
      - NE 10244: 2

Experts

1.	Boissier, S: 1 article (06/2000)
2.	Clézardin, P: 1 article (06/2000)
3.	Colombel, M: 1 article (06/2000)
4.	Delaissé, J M: 1 article (06/2000)
5.	Delmas, P: 1 article (06/2000)
6.	Ebetino, F H: 1 article (06/2000)
7.	Ferreras, M: 1 article (06/2000)
8.	Magnetto, S: 1 article (06/2000)
9.	Peyruchaud, O: 1 article (06/2000)

Related Diseases

1.

Neoplasms (Cancer)

09/15/1997 - "NE-58051, the inactive pyridylpropylidene analogue of risedronate, had no inhibitory effect on tumor cell adhesion compared to that observed with its active counterpart NE-10244, suggesting that the mechanism of action of BP on tumor cells involved a stereospecific recognition step. "
06/01/2000 - "In addition, NE-58051 (the inactive pyridylpropylidene analogue of risedronate) had no inhibitory effect, whereas NE-10790 (a phosphonocarboxylate analogue of risedronate in which one of the phosphonate groups is substituted by a carboxyl group) inhibited tumor cell invasion to an extent similar to that observed with NE-10244, indicating that the inhibitory activity of BPs on tumor cells involved the R2 chain of the molecule. "
06/01/2000 - "The order of potency for four BPs in inhibiting tumor cell invasion was: zoledronate > ibandronate > NE-10244 (active pyridinium analogue of risedronate) > clodronate. "
09/15/1997 - "The order of potency for four BPs in inhibiting tumor cell adhesion to extracellular matrices was found to be: ibandronate > NE-10244 (antiresorptive active pyridinium analogue of risedronate) > pamidronate > clodronate. "

Related Drugs and Biologics

1.	Clodronic Acid (Clodronate)
2.	Ibandronic Acid (Boniva)
3.	Risedronic Acid (Actonel)
4.	NE 58051
5.	Organophosphonates (Phosphonates)
6.	Pamidronate (Aredia)
7.	Zoledronic Acid (Zometa)
8.	2- (3- pyridinyl)- 1- hydroxyethylidene- 1,1- phosphonocarboxylic acid