matrix metalloproteinase 19

mainly from human placenta, lung, pancreas, overy, spleen and intestine; maps to chromosome 12q14; amino acid sequence in first source

Also Known As:

MMP 19; MMP-19; MMP18 protein, human; MMP19 protein, human; Mmp19 protein, mouse; RASI-1 protein, human; matrix metallopeptidase 19, human; matrix metallopeptidase 19, mouse; matrix metalloproteinase RASI, human

Networked: 47 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sedlacek, R: 5 articles (01/2016 - 07/2004)
2.	Impola, Ulla: 5 articles (09/2006 - 01/2003)
3.	Saarialho-Kere, Ulpu: 5 articles (01/2005 - 01/2003)
4.	López-Otín, Carlos: 3 articles (05/2006 - 11/2003)
5.	Saarialho-Kere, U: 3 articles (04/2005 - 01/2004)
6.	Kanchev, I: 2 articles (01/2016 - 01/2014)
7.	Sedlacek, Radislav: 2 articles (01/2012 - 11/2003)
8.	Djonov, Valentin: 2 articles (11/2010 - 01/2007)
9.	Foidart, Jean-Michel: 2 articles (09/2010 - 05/2006)
10.	Cho, Hyojin: 2 articles (12/2008 - 08/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2022 - "The expression of MMP-19 on vessels was also significantly different between peritumoral and cancer tissues (higher levels in peritumoral tissue). " 12/01/2022 - "There were significant differences between the expression of MMP-19 on macrophages and vessels among healthy and cancer tissues. " 01/01/2019 - "Furthermore, rescue assays indicated that circ-ERBB2 promoted tumor growth and invasion via miR-503/CACUL1 and miR-637/MMP-19 pathways, respectively. " 10/01/2007 - "Local immunoreactivity for MMP-19 was positively correlated with tumor invasiveness as reflected in its structural characteristics and the degree of nuclear polymorphism, and negatively correlated with the inflammatory response of the host. " 10/01/2007 - "Local immunoreactivity for MMP-19 was positively correlated with tumor invasiveness as reflected in its structural characteristics and the degree of nuclear polymorphism, and negatively correlated with the inflammatory response of the host. "
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/01/2004 - "In inflammatory bowel disease (IBD), MMP- 19 was expressed in nonmigrating enterocytes and shedding epithelium. " 01/01/2014 - "In this study, we analysed the expression of MMP-19 in the main forms of gastrointestinal diseases including inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease, and colorectal carcinoma. "
3.	Glioma (Gliomas) 02/01/2013 - "The aim of this study was to investigate whether co-expression of MMP-14 and MMP-19 has prognostic relevance in human gliomas. " 02/01/2013 - "Furthermore, the co-expression of MMP-14 and MMP-19 was additively and more significantly (P = 0.006) associated with adverse prognosis in patients with gliomas than respective expression of MMP-14 and MMP-19. " 02/01/2013 - "Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma." 02/01/2013 - "These findings indicated for the first time that the co-expression of MMP-14 and MMP-19 is significantly correlated with prognosis in glioma patients, suggesting that the co-expression of these proteins may be used as both an early diagnostic and independent prognostic marker." 02/01/2013 - "The expression levels of MMP-14 and MMP-19 proteins in glioma tissues were both significantly higher (both P < 0.001) than those in non-neoplastic brain tissues according to the immunohistochemistry analysis, which was confirmed by the western blot analysis. "
4.	Fibrosis (Cirrhosis) 01/01/2012 - "The aim of this study was to elucidate the role of MMP-19 during the development and resolution of fibrosis by comparing the response of MMP-19-deficient (MMP19KO) and wild-type mice upon chronic liver CCl(4)-intoxication. " 03/15/2015 - "We have recently found that matrix metalloproteinase 19 (MMP-19)-deficient (Mmp19-/-) mice develop an exaggerated bleomycin-induced lung fibrosis, but the mechanisms are unclear. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2014 - "In this study, we analysed the expression of MMP-19 in the main forms of gastrointestinal diseases including inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease, and colorectal carcinoma. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Proteins (Proteins, Gene)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
5.	Antibodies
6.	Messenger RNA (mRNA)
7.	Connective Tissue Growth Factor
8.	Tissue Inhibitor of Metalloproteinase-2
9.	Tissue Inhibitor of Metalloproteinase-1
10.	Zinc

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Therapeutics