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alpha-methylacyl-CoA racemase

Subscribe to New Research on alpha-methylacyl-CoA racemase

involved in catabolism of branched-chain fatty acids derived from isoprenoids; acts on pristanoyl-CoA and trihydroxycoprostanoyl-CoA, but not on 3-methyl branched-chain or linear-chain acyl CoAs

Also Known As:

2-methylacyl-CoA racemase; AMACR protein, human; Amacr protein, mouse; Amacr protein, rat; MeAc CoA racemase; P504S protein, human; alpha-methylacyl-CoA racemase, human; alpha-methylacyl-CoA racemase, mouse; alpha-methylacyl-CoA racemase, rat

Networked: 159 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Isomerases: 29
    - Racemases and Epimerases: 4
      - alpha-methylacyl-CoA racemase: 159

Experts

1.	Jiang, Zhong: 13 articles (02/2007 - 07/2002)
2.	Isaacs, William B: 10 articles (07/2009 - 04/2002)
3.	Chinnaiyan, Arul M: 9 articles (06/2005 - 07/2002)
4.	Rubin, Mark A: 9 articles (06/2005 - 07/2002)
5.	Yang, Ximing J: 8 articles (10/2009 - 07/2002)
6.	Epstein, Jonathan I: 8 articles (07/2009 - 06/2003)
7.	Woda, Bruce A: 8 articles (09/2006 - 07/2002)
8.	Cheng, Liang: 7 articles (04/2014 - 02/2007)
9.	Martignoni, Guido: 5 articles (01/2010 - 06/2008)
10.	Gobbo, Stefano: 5 articles (01/2010 - 06/2008)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 09/15/2008 - "Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population." 12/01/2005 - "Studies using a monoclonal (P504S) and a polyclonal antibody (p-AMACR) to alpha-methylacyl-CoA racemase (AMACR) have shown variable expression in prostate cancer (PCa). " 09/01/2004 - "Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker." 03/01/2004 - "This study uses the AQUA system to assess a recently described prostate cancer biomarker, alpha-methylacyl-CoA-racemase (AMACR), and to determine the effectiveness of the quantitative measurement of this marker as a means for making the diagnosis of prostate cancer. " 04/15/2002 - "In this study, we describe a gene, alpha-methylacyl-CoA racemase (AMACR), whose expression is consistently up-regulated in prostate cancer. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2004 - "Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma." 09/01/2008 - "We conclude that Ulex europaeus agglutinin 1 reactivity and positivity for E-cadherin and c-KIT are effective in distinguishing collecting duct carcinoma from papillary renal cell carcinoma, and that negative results for alpha-methylacyl CoA racemase and CD10 are potentially useful hallmarks of this distinction also. " 01/01/2010 - "We performed fluorescent in situ hybridization (FISH) to investigate the numeric change of chromosomes 7, 17, and Y and loss of chromosome 3p in "papillary renal cell carcinomas (RCC) with extensive clear cell changes (CCC)." Consecutive cases of RCC over a 12-year period were reviewed to identify "papillary RCC with extensive CCC." Immunostaining for cytokeratin 7 and alpha-methylacyl-CoA racemase (AMACR) and FISH for chromosomes 7, 17, Y, and 3p were applied. " 09/01/2008 - "alpha-Methylacyl-CoA racemase (AMACR)/P504S has been reported to be positive in prostatic adenocarcinoma, papillary renal cell carcinoma, and gastrointestinal neoplasmas; however, it has never been studied in clear cell carcinoma of the lower urinary tract. " 07/01/2009 - "Our study demonstrates that tubulocystic carcinoma and collecting duct carcinoma have different expression profiles of selected genes, including vimentin, p53, and alpha methylacyl CoA racemase. "
3.	Carcinoma (Carcinomatosis) 05/01/2013 - "With the present study we aimed to compare the pattern of expression of MCT2 and alpha-methylacyl-CoA racemase (AMACR), in prostate carcinoma, PIN lesions, non-neoplastic prostate tissue, and normal prostate and compare their sensitivity and specificity. " 02/01/2007 - "alpha-methylacyl-CoA racemase expression may be substantially diminished or entirely lost in prostate carcinoma after hormonal therapy. " 09/01/2006 - "Alpha methylacyl-CoA-racemase (AMACR), also known as P504S, has been widely used as a positive marker for the diagnosis of prostate carcinoma in clinical practice. " 09/01/2006 - "Sensitivity of P504S/alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry for the detection of prostate carcinoma on stored needle biopsies." 03/01/2006 - "Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression."
4.	Neoplasms (Cancer) 10/29/2015 - "Alpha-methylacyl-CoA racemase (AMACR) is over-expressed in many cancer types and can serve as a novel diagnostic biomarker. " 01/20/2015 - "We use of this technique to separate prostate tumor and benign cells in human prostate needle biopsies based on the expression levels of the tumor marker alpha-methylacyl-CoA racemase (AMACR). " 01/01/2015 - "Alpha-methylacyl-CoA racemase (AMACR), an intracellular enzyme involved in lipid metabolism, has emerged as an immunohistochemical marker for many types of cancer. " 04/01/2014 - "If a case is still considered atypical by a uropathology expert after negative basal cell staining, positive staining for alpha-methylacyl-CoA-racemase can help establish in 50% of these cases a definitive diagnosis of cancer." 07/01/2013 - "The role of alpha-methylacyl-CoA racemase (AMACR) in pathogenesis and diagnosis of different types of cancer has been investigated during last decade. "
5.	Adenocarcinoma 01/01/2008 - "Alpha-methylacyl-CoA racemase expression is upregulated in gastric adenocarcinoma: a study of 249 cases." 01/01/2013 - "Alpha methylacyl-CoA racemase (AMACR) is a useful diagnostic marker for prostate adenocarcinoma. " 01/01/2013 - "Alpha methylacyl-CoA racemase (AMACR) in prostate adenocarcinomas from Japanese patients: is AMACR a "race"-dependent marker?" 12/01/2011 - "Alpha-methylacyl-CoA racemase (AMACR) is highly expressed in prostatic adenocarcinoma. " 02/01/2007 - "Alpha-methylacyl-CoA racemase (P504S)/34betaE12/p63 triple cocktail stain in prostatic adenocarcinoma after hormonal therapy."

Related Drugs and Biologics

1.	Antigens
2.	Cadherins (E-Cadherin)
3.	Fatty Acids (Saturated Fatty Acids)
4.	Prostate-Specific Antigen (Semenogelase)
5.	Vimentin
6.	Keratin-7 (Cytokeratin 7)
7.	Keratins (Keratin)
8.	Biological Markers (Surrogate Marker)
9.	Transcription Factors (Transcription Factor)
10.	Phytanic Acid

Related Therapies and Procedures

1.	Massage (Reflexology)
2.	Prostatectomy (Retropubic Prostatectomy)